Clinical Trials Directory

We are doing this study to find the most effective, safe dose of an experimental drug called ziftomenib (the study drug) to be used in combination with an established dose of imatinib for people who have advanced gastrointestinal stromal tumors (GIST) and failed treatment with imatinib on its own.

We are doing this study to compare 2 different surgeries for epithelial ovarian cancer. We want to know if an investigational surgical procedure called minimally invasive surgery can offer better results than the standard surgery, which is called laparotomy. We hope to find out if one procedure or the other is preferable when it comes to preventing cancer from returning and giving patients a better quality of life after their surgery.

We are doing this study to find out how changes in air pressure can affect people's exercise capacity. We want to compare how these pressure changes affect the abilities of healthy volunteers and compare their changes to those of people who are diagnosed with HFpEF (heart failure with a preserved ejection fraction, a congestive heart disease).

We are doing this study to find out if an experimental drug called LB-1908 (the study drug) is a safe and effective treatment for different types of gastrointestinal cancers. The study drug is custom-made for each participant from their own white blood cells or T-cells. We collect these cells using a procedure called apheresis.

We are doing this study to support vaccine development by studying blood cells of the immune system.

We are doing this study to learn more about why the right side of the heart doesn't work well in certain heart conditions. We're using heart tissue samples from people with specific heart problems to help us make these important discoveries.

We are doing this study to collect blood and cerebrospinal fluid samples from patients who have breast cancer that has spread to the brain and/or spinal cord. We hope that by analyzing these samples, we can find out how effective different cancer medications are at treating metastases to the leptomeninges (tissue that surrounds the brain and spinal cord). We also want to do genetic testing on these samples to look for cancer mutations that can give us clues about how people might respond to different therapies or which therapies are most likely to be helpful.

We are doing this study to find the most effective, safe dose of an experimental drug called LNS8801 (the study drug) when it is given with or without pembrolizumab to people who have treatment-refractory unresectable melanoma.