Clinical Trials Directory

436 clinical trials found.
Cancer Immunotherapy

We are doing this study to find out if an experimental drug called LB-1908 (the study drug) is a safe and effective treatment for different types of gastrointestinal cancers. The study drug is custom-made for each participant from their own white blood cells or T-cells. We collect these cells using a procedure called apheresis.

Compensation: No
Oncology
Research for Healthy Adults

We are doing this study to support vaccine development by studying blood cells of the immune system.

Compensation: No
Non-Oncology
Heart and Circulation

We are doing this study to learn more about why the right side of the heart doesn't work well in certain heart conditions. We're using heart tissue samples from people with specific heart problems to help us make these important discoveries.

Compensation: No
Ages: 18-110
Non-Oncology
Duke University Hospital
Brain and Spine Metastasis

We are doing this study to collect blood and cerebrospinal fluid samples from patients who have breast cancer that has spread to the brain and/or spinal cord. We hope that by analyzing these samples, we can find out how effective different cancer medications are at treating metastases to the leptomeninges (tissue that surrounds the brain and spinal cord). We also want to do genetic testing on these samples to look for cancer mutations that can give us clues about how people might respond to different therapies or which therapies are most likely to be helpful.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Hematologic Malignancies and Cellular Therapy

We are doing this study to find out if an experimental technology is a safe and effective way to administer treatment for relapsed and/or refractory multiple myeloma (RRMM). We want to know if giving the drug isatuximab as an injection under the skin works as well as giving this same drug as an intravenous (IV) infusion. The drug combination of isatuximab, carfilzomib, and dexamethasone is approved for the treatment of RRMM, but the current standard of care is to give isatuximab through an IV.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Brain and Spine Metastasis

We are doing this study to find out if an experimental drug called LY3962673 (the study drug) is a safe and effective option for cancer that has a KRAS G12D mutation. We are also trying to find the best dose level to use.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Hematologic Malignancies and Cellular Therapy

We are doing this study to find out if an experimental drug called AbbV-383 (the study drug) is safe and effective for patients with relapsed/refractory multiple myeloma.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Skin, Hair and Nails

We are doing this study to find out if an experimental drug called upadacitinib (the study drug) is a safe and effective option for people with moderate to severe hidradenitis suppurativa (HS) who did not get adequate relief from standard treatment.

Compensation: Yes
Ages: 12-110
Non-Oncology
Duke University Hospital