Clinical Trials Directory

We are doing this study to find out if avelumab is a safe and effective option for triple negative metastatic breast cancer when it is combined with different anti-cancer drugs.

If you choose to join this study, you will:
- Be randomized to Group 1 or Group 2
-- Group 1 will get the study drug (Sulindac)
-- Group 2 will get a placebo (harmless sugar pill)

Both groups will have:
- CT scans (body scan)
- Endoscopy's (a way to look at your digestive tract)
- Collection of cyst fluid from the pancreas

We are doing this study to learn more about how nicotine levels in cigarettes impact the relationship between smoking and pain. We want to know if changing the nicotine content in cigarettes can alter any pain that smokers have. We hope the information from this study will lead to treatments that make it easier for smokers with pain to quit smoking.

We are doing this study to find out if an ophthalmic insert called Dextenza can be used to control eye inflammation and pain in pediatric patients after routine retinal surgery or laser treatment.

If you choose to join this study, you will:
- Allow us to collect leftover tissue from your surgery, a small blood sample, and urine to use for future research
- Complete study questionnaires
- Agree for us to collect clinical data from your medical record related to your cancer and treatment

We are doing this to compare the results of early surgical intervention to medical therapy. We want to know if there is a difference in outcomes for these treatment options. We also want to track the health and progress of people with a large ascending aortic aneurysm (a bulge in the aorta caused by weakening in the artery wall).

If you choose to join this study, you will:
- Be randomized (like the flip of a coin) to screening with Tomosynthesis Mammography (TM) or Digital Mammography (DM)

The frequency and number of screening mammograms will vary with your menopausal status and whether you have breast cancer risk factors.
-- All premenopausal women will have annual screening

-- Postmenopausal women will have screening every 2 years unless they have any specific risk factors

- Have either three-dimensional (3D) Tomosynthesis Mammography or two-dimensional (2D) Digital Mammography

-- Get screened every year for four more years - for a total of five mammograms, or
-- Every other year - for a total of three mammograms

- Be followed for 4.5 to 8 years

We are doing this study to see how an experimental drug called evolocumab (study drug) works in your body and against your cancer when it is given in combination with approved immunotherapy drugs.