Clinical Trials Directory

456 clinical trials found.
Hematologic Malignancies and Cellular Therapy

We are doing this study to find out if an experimental drug called AbbV-383 (the study drug) is safe and effective for patients with relapsed/refractory multiple myeloma.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Skin, Hair and Nails

We are doing this study to find out if an experimental drug called upadacitinib (the study drug) is a safe and effective option for people with moderate to severe hidradenitis suppurativa (HS) who did not get adequate relief from standard treatment.

Compensation: Yes
Ages: 12-110
Non-Oncology
Duke University Hospital
Heart and Circulation

We are doing this study to learn more about the sounds coming from a Doppler device when testing arteries. The recording will be used to train a computer program to compare the sounds from healthy arteries to non-healthy arteries.

Compensation: No
Non-Oncology
Research for Healthy Adults

We are doing this study to understand how environmental exposures may be involved in lung function. We want to find out how immune cells in the lungs are affected by irritants that are present in the environment.

Compensation: Yes
Ages: 18-55
Non-Oncology
Duke University Hospital, Other
Heart and Circulation

We are doing this study to learn more about ATTR and its different variants and how they can can be better diagnosed, managed, and treated.

Compensation: Yes
Ages: 18-110
Non-Oncology
Duke University Hospital
Heart and Circulation

We are doing this study to find out if an experimental drug called NTLA-2001 (the study drug) is a safe and effective option for people with transthyretin amyloidosis with cardiomyopathy (ATTR-CM). The study drug is made using the CRISPR-CaS9 gene editing system. The intent of the study drug that is being tested is to target the TTR gene and make it inactive.

Compensation: Yes
Ages: 18-90
Non-Oncology
Duke University Hospital
Heart and Circulation

We are doing this study to learn more about heart valve disease and its standard-of-care treatments, and we want to learn more about the safety and performance of the Corcym devices and accessories used for heart valve disease.

Compensation: Yes
Ages: 18-110
Non-Oncology
Duke University Hospital
Heart and Circulation

In the first part of the study, some people will get a new medicine called maridebart cafraglutide. They will get small shots that slowly increase in amount over 16 weeks. Other people will get a fake medicine called a placebo, but the shots will look the same. After this first part, people who stay in the study can join the second part. In this part, everyone will get the real medicine for about 2 years. Doctors will keep checking to see how well the medicine works and if it is safe.

Compensation: Yes
Ages: 18-110
Non-Oncology
Duke University Hospital