Clinical Trials Directory
In this study, people will be placed into one of three groups by chance. One group will receive a medicine called zanzalintinib by mouth every day and another medicine called MK 3475A as an injection every three weeks. A second group will receive only zanzalintinib each day. The third group will receive a placebo pill that looks like zanzalintinib but has no active medicine. People in the second and third groups will not know which one they are receiving. During the study, participants will have regular clinic visits and medical tests to check their health and how well the treatment is working. The study medicine may be given for up to two years, and participants may be followed for up to five years so researchers can continue to monitor their health and study results.
This study is about helping astronauts stay safe during moonwalks. When astronauts go to the moon, they wear special suits with lower air pressure, which can cause small bubbles to form in the body. These bubbles can cause a problem called decompression sickness, which may lead to pain or weakness. To help prevent this, astronauts breathe pure oxygen before their moonwalk. In this study, people will breathe oxygen for about one hour while resting or doing different levels of exercise. After that, they will enter a special room that lowers air pressure to feel like being in a spacesuit. While inside, they will do light exercises and have ultrasound tests to look for bubbles in the body. This part lasts about six hours. The goal is to learn how well oxygen breathing and activity help prevent decompression sickness.
The study begins with a long screening period that can last up to one year. During this time, doctors will do tests to see if a person can join. If they qualify, they will go through a transplant process that may include treatments before the transplant and a hospital stay. After the transplant, recovery time can vary, but it may take one month or longer. Participants will have many follow up visits, starting with twice a week for three months, then once a week for three months, and then once a month for up to one year. The study continues for as long as the participant is alive, so doctors can learn about long term outcomes.