Clinical Trials Directory

403 clinical trials found.
Hematologic Malignancies and Cellular Therapy

We are doing this study to find out if an experimental drug called KO-539 (study drug) is a safe and effective treatment for AML. We want to know if it might be beneficial for people with AML that is resistant to standard treatments.

Compensation: No
Oncology
Gynecologic Cancer

We are doing this study to compare 2 different surgeries for epithelial ovarian cancer. We want to know if an investigational surgical procedure called minimally invasive surgery can offer better results than the standard surgery, which is called laparotomy. We hope to find out if one procedure or the other is preferable when it comes to preventing cancer from returning and giving patients a better quality of life after their surgery.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital, Duke Raleigh Hospital
Gastrointestinal Cancer

We are doing this study to see if the study drugs, LBL-007 plus tislelizumab in combination with bevacizumab plus capecitabine, are safe and effective for treating metastatic or unresectable colorectal cancer.

Compensation: No
Oncology
Research for Healthy Adults

We are doing this study to find out how changes in air pressure can affect people's exercise capacity. We want to compare how these pressure changes affect the abilities of healthy volunteers and compare their changes to those of people who are diagnosed with HFpEF (heart failure with a preserved ejection fraction, a congestive heart disease).

Compensation: Yes
Ages: 30-110
Non-Oncology
Other
Research for Healthy Adults

We are doing this study to support vaccine development by studying blood cells of the immune system.

Compensation: No
Non-Oncology
Lungs and Breathing

We are doing this study to find out why some young adults have better lung function than others during the period of peak lung health (ages 25 to 35 years old) for most people. We want to learn how people's actions or exposures can affect lung function and risk of future lung disease. These factors might include smoking, vaping, or diet and environmental exposures to pollution and allergens.

Compensation: Yes
Ages: 25-35
Non-Oncology
Remote/online, Other
Brain and Spine Metastasis

We are doing this study to find the most effective and safe dose of an experimental drug called LY3537982 (the study drug) for people who have NSCLC that has KRAS G12C mutations.

Compensation: Yes
Ages: 18-100
Oncology
Duke University Hospital, Duke Raleigh Hospital
Genitourinary Cancer

We are doing this study to find out if an experimental drug called ABBV-CLS-484 (the study drug) is a safe and effective option for patients who have certain types of cancers that involve solid tumors, such as head and neck, lung, or kidney cancers. This study will also help determine what dose of the study drug works best when it is given either alone or in combination with pembrolizumab or cabozantinib.

Compensation: No
Oncology