Clinical Trials Directory
In this study, participants will first receive chemotherapy for one to three days to lower their immune system. After that, they will receive special CAR T cells in the hospital and stay there so doctors can watch them closely. For the first month after receiving the cells, participants will be monitored very carefully and must stay near the study center for about 30 days. After that, they will return to the clinic once a month for at least two years so doctors can continue to check their health.
The study team will use brain scans and simple tests to understand who is more likely to regain vision. Participation in the study will last about 9 months and will include 4 in‑person visits to the Duke University Neuromodulation and Stroke Recovery Lab.
People in this study will be placed into one of two groups by chance, like flipping a coin. One group will get two medicines called DSP107 and Atezolizumab together. The other group will get a medicine called Fruquintinib by itself. Each treatment cycle lasts 4 weeks and can continue for up to 2 years. Doctors will check health and safety during the study. After the last dose, there will be a follow-up period of up to 90 days.
We have created this repository as a way for people to let us know they are interested in being contacted about future research studies. These studies will aim to improve the health and wellbeing of people by using mobile technology or other interventions. If you would like more information please contact us at dbhtl@duke.edu
Researchers will collect information from participants medical records and place it in a secure database. During planned blood draws, they may collect a small amount of extra blood for current or future research. Participants may also be asked to provide a cheek swab or saliva sample that can be used for current or future research studies.
Our Duke Vaccine and Trials Unit Volunteer Registry is a way for people to let our team know that you are interested in learning more about any of our vaccine studies. For more information or to sign up, visit us at: https://redcap.duke.edu/redcap/surveys/?s=WPL7XPK4JYHY4NYK