Clinical Trials Directory

473 clinical trials found.
Skin Cancer - Melanoma

We are doing this study to find out if an experimental drug called acasunlimab (the study drug) is a safe and effective option for adults with relapsed/refractory, unresectable, locally advanced, or metastatic cutaneous melanoma that has progressed despite treatment with a checkpoint inhibitor. We want to know how well the study drug works on its own and in combination with pembrolizimab.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Digestive System

We are doing this study to learn from patients' experiences about managing gastroesophageal reflux (GERD) and other risks related to lung transplantation.

Compensation: No
Ages: 18-110
Non-Oncology
Other

In this study, people will answer questions and do simple physical tests three times over six months. They will be randomly placed into one of two groups: one gets coping skills training with a nurse by phone, and the other gets regular care. Everyone will also get a short health check during cancer visits to look for problems like memory loss or falling.

Compensation: Yes
Ages: 65-110
Duke University Hospital, Duke Regional Hospital, Duke Raleigh Hospital, Other
Gynecologic Cancer

We are doing this study to find out if giving heated chemotherapy into the belly, a procedure known as heated intraperitoneal chemotherapy (HIPEC), can improve treatment results for patients with ovarian cancer.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Gynecologic Cancer

We are doing this study to find the most effective, safe dose of an experimental drug called raludotatug deruxtecan (the study drug) and to see if your disease or medical condition improves while taking it.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital, Duke Raleigh Hospital
Gynecologic Cancer

We are doing this study to find out if an experimental drug called MK-2870 (the study drug) is a safe and effective option for people with cervical cancer. We want to see how well it works compared to the standard treatment for this diagnosis.

Compensation: No
Oncology
Gynecologic Cancer

We are doing this study to find out if an experimental drug called Rina-S (the study drug) is a safe and effective option for ovarian cancer that is not improving with standard treatments.

Compensation: No
Ages: 18-64
Oncology
Duke University Hospital