Purpose of this Study
We are doing this study to collect blood and cerebrospinal fluid samples from patients who have breast cancer that has spread to the brain and/or spinal cord. We hope that by analyzing these samples, we can find out how effective different cancer medications are at treating metastases to the leptomeninges (tissue that surrounds the brain and spinal cord). We also want to do genetic testing on these samples to look for cancer mutations that can give us clues about how people might respond to different therapies or which therapies are most likely to be helpful.
Who Can Participate?
Eligibility
Adults ages 18+ who:
- Are diagnosed with breast cancer
- Have metastases (spread) to the leptomeninges (tissue that covers the brain and spinal cord)
- Are undergoing or planning treatment with a systemic therapy (includes chemotherapy, hormone therapy, targeted therapy, and immune therapy) or intrathecal therapy (administration of drugs via an injection into the spinal canal) for their disease
Age Range
18-110
Sex/Genders
Male (cisgender)
Female (cisgender)
Non-binary or gender fluid
Transgender male
Transgender female
Looking for Healthy Participants
No
What is Involved?
Description
If you choose to join this study, you will donate blood and cerebrospinal fluid (CSF) samples that can be used for research. We will collect the blood and CSF samples from you during your regular visits to Duke when you will have a routine blood draw or lumbar puncture as part of your normal treatment.
Locations
Duke University Hospital
Visit Timing
Weekdays
Compensation
No
Spanish Materials Available
No
Study Details
Full Title
A Prospective Registry for Patients with Metastatic Breast Cancer and Leptomeningeal Metastases
Principal Investigator
Carey
Anders
Protocol Number
PRO00116788
NCT ID
NA
Phase
N/A
Enrollment Status
Pending Open to Enrollment