Clinical Trials Directory

434 clinical trials found.
Hematologic Malignancies and Cellular Therapy

We are doing this study to find out if an investigational drug called HM43239 (the study drug) is a safe and effective option for people who have AML that came back after remission or did not respond to standard treatments. We also want to find out what dose of the study drug works best for most patients.

Compensation: No
Oncology
Heart and Circulation

We are doing this study to learn more about children with atrioventricular septal defect. We hope to improve care for patients with this condition in the future.

Compensation: No
Ages: 0-18
Non-Oncology
Duke University Hospital
Thoracic Cancer

We are doing this study to find the most effective, safe dose of an experimental drug called amivantamab (the study drug) when it is given in combination with lazertinib and chemotherapy. We want to know if this study drug regimen is effective for people with non-small cell lung cancer (NSCLC) who have a specific mutation in the EGFR (epidermal growth factor receptor) gene.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital, Duke Raleigh Hospital
Lungs and Breathing

We are doing this study to find out if breathing exercises can improve lung function for kids who have asthma.

Compensation: Yes
Ages: 6-17
Non-Oncology
Duke University Hospital

We are doing this study to find out if an experimental drug called pegozafermin (the study drug) is a safe and effective option for people with Metabolic Dysfunction Associated Steatohepatitis (MASH).

Compensation: Yes
Ages: 18-75
Duke University Hospital
Phase I

If you decide to participate in this study, you will have a screening visit to see if you meet the criteria to be included in this study. If you are eligible, you will proceed to the study drug period. During this period, you will:

  • Take the study drug tablets by mouth at about the same time each morning and within 30 minutes of finishing your breakfast for the first 15 days
  • After the first 15 days, continue to take the study drug by mouth at approximately the same time every day, within 30 minutes of finishing a meal (breakfast, lunch, or dinner) of your choice
The following tests and procedures will be performed throughout the study:
  • Blood draws
  • Imaging tests (CT, PET/CT and MRI)
  • ECG

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Genitourinary Cancer

We are doing this study to find out if an experimental drug called STM-416 (the study drug) is a safe and effective option for patients with a history of high grade, non-muscle invasive bladder cancer (cancer only within the bladder) whose disease has returned and who require an operation to remove cancer from the bladder.

Compensation: Yes
Ages: 18-110
Oncology
Duke University Hospital
Hematologic Malignancies and Cellular Therapy

We are doing this study to find the most effective, safe dose of an experimental drug called talquetamab (the study drug) for people with relapsed/refractory multiple myeloma. We want to compare how the study drug works on its own to how it works in combination with different drugs.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital