Clinical Trials Directory

471 clinical trials found.
Hematologic Malignancies and Cellular Therapy

We are doing this study to find out if an investigational drug called HM43239 (the study drug) is a safe and effective option for people who have AML that came back after remission or did not respond to standard treatments. We also want to find out what dose of the study drug works best for most patients.

Compensation: No
Oncology
Heart and Circulation

We are doing this study to learn more about children with atrioventricular septal defect. We hope to improve care for patients with this condition in the future.

Compensation: No
Ages: 0-18
Non-Oncology
Duke University Hospital
Lungs and Breathing

We are doing this study to find out if breathing exercises can improve lung function for kids who have asthma.

Compensation: Yes
Ages: 6-17
Non-Oncology
Duke University Hospital
Eyes and Vision

This study is trying to find out how well a new medicine called 4D-150 works compared to a medicine called Eylea in adults who have a kind of eye disease called wet age-related macular degeneration (wet AMD). The medicine is given as a shot directly into the eye. The study also wants to make sure the new medicine is safe and lasts a long time.

Compensation: Yes
Ages: 50-110
Non-Oncology
Duke University Hospital
Endocrine and Metabolic System

We are doing this study to find out if an experimental drug called pegozafermin (the study drug) is a safe and effective option for people with Metabolic Dysfunction Associated Steatohepatitis (MASH).

Compensation: Yes
Ages: 18-75
Non-Oncology
Duke University Hospital
Phase I

If you decide to participate in this study, you will have a screening visit to see if you meet the criteria to be included in this study. If you are eligible, you will proceed to the study drug period. During this period, you will:

  • Take the study drug tablets by mouth at about the same time each morning and within 30 minutes of finishing your breakfast for the first 15 days
  • After the first 15 days, continue to take the study drug by mouth at approximately the same time every day, within 30 minutes of finishing a meal (breakfast, lunch, or dinner) of your choice
The following tests and procedures will be performed throughout the study:
  • Blood draws
  • Imaging tests (CT, PET/CT and MRI)
  • ECG

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Brain, Spinal Cord and Nerves

We are doing this study to find out if an experimental drug called XEN1101 (the study drug) is a safe and effective option for people who have epilepsy and are experiencing generalized tonic clonic seizures.

Compensation: Yes
Ages: 12-110
Non-Oncology
Other
Heart and Circulation

This study lasts for about 41 weeks. It starts with a screening period, followed by around 6 months of taking either the study medicine or a placebo, and ends with a follow-up visit. People who join will be randomly chosen to get either a low dose or high dose of the medicine called PKN605, or a placebo, which is a pill that does not have any medicine in it. During the study, participants will go to the clinic regularly. They will wear a heart monitor patch, use a small device at home to check their heart, and have blood tests and other health checks. These tests help doctors learn how the medicine works and if it is safe.

Compensation: Yes
Ages: 18-110
Non-Oncology
Duke University Hospital, Other