Clinical Trials Directory
This study is about helping astronauts stay safe during moonwalks. When astronauts go to the moon, they wear special suits with lower air pressure, which can cause small bubbles to form in the body. These bubbles can cause a problem called decompression sickness, which may lead to pain or weakness. To help prevent this, astronauts breathe pure oxygen before their moonwalk. In this study, people will breathe oxygen for about one hour while resting or doing different levels of exercise. After that, they will enter a special room that lowers air pressure to feel like being in a spacesuit. While inside, they will do light exercises and have ultrasound tests to look for bubbles in the body. This part lasts about six hours. The goal is to learn how well oxygen breathing and activity help prevent decompression sickness.
We are doing this study to evaluate an experimental technology called the Reprieve Decongestion Management System (the study device) for heart failure patients with fluid overload. The study device is designed to help people with heart failure feel better by removing extra fluid from their body quickly. The device is programmed to deliver an appropriate amount of medication at the right time to help people shed extra fluid through urination. We want to know if this device works better than the standard treatment. The standard treatment is to prescribe diuretics (medication to increase urination) at a specified dose and dosage schedule.
We are doing this study to examine genetic changes in your tumor that may contribute to resistance to immunotherapy. With this information, we hope to be able to identify new treatment methods as well as improve our ability to identify patients more likely to respond to immunotherapy.
After the screening, the study will last up to one year and has two parts. People in the study will be randomly placed into two groups. In Part A, one group will get the study medicine, and the other group will get a placebo, which looks like the medicine but does not do anything. In Part B, everyone will get the study medicine. The medicine or placebo will be given through a tube into a vein in the arm. During the study, everyone will have checkups, give blood samples, have kidney tissue samples taken (called biopsies), and answer questions about how they feel.