Clinical Trials Directory
We are doing this study to find the most effective, safe dose of an experimental drug called raludotatug deruxtecan (the study drug) and to see if your disease or medical condition improves while taking it.
This study has two parts. The first part is called the Screening Period and lasts about 12 weeks. During this time, people will visit the doctor 5 to 7 times. They will have tests like checking their genes, memory tests, brain scans, a spinal tap, and other exams like blood tests and skin checks. The second part is called the Study Dosing Period. In this part, people will be randomly chosen to take either a study medicine or a fake pill that looks the same. They will take one pill every day for 5 to 8 years. During this time, they will go to the doctor every few months to answer questions, get exams, and have more tests like brain scans and lab work.
We are doing this study to collect data about the use and safety of the GORE TAG Conformable Thoracic Stent Graft®. This device is approved by the FDA for the endovascular repair of medical conditions of the aorta (the large blood vessel that runs inside the chest and abdomen).
In this study, people will have a device called the Gore TAMBE placed in their body. After the device is placed, doctors will check on them at about one month, six months, and then once each year for ten years. At these visits, people will have a physical exam, blood tests, CT scans, and tests to check how their brain and nerves are working.
In this study, people will be treated with the Gore TBE device as part of their regular surgery planned by their doctor. The study will collect information from normal follow up visits for up to ten years. Participants will also be asked to fill out a questionnaire before surgery and again at each follow up visit to help doctors understand how they are doing over time.
We are doing this study to find out if an investigational drug called OpRegen (the study drug) is a safe and effective option for older adults who have geographic atrophy (GA) secondary to age-related macular degeneration (AMD). We also want to know if a procedure called subretinal surgical delivery is an effective way to give people the study drug.