Clinical Trials Directory

We are testing a new type of electrode and a special computer system that can read signals from the skin. The person in the study will wear these new electrodes on their feet.

We are doing this study to get more information about the safety and performance of the Signia® circular adapter and stapler (the study technology). This device is FDA-approved for use as a tool to connect or re-connect tissues after a surgery. We want to know how successful it is at promoting healing for people who have left sided colon, sigmoid, or rectal resections at Duke.

We are doing this study to find out if an investigational drug called RGN-259 Thymosin Beta 4 eye drops solution (the study drug) is a safe and effective option for the treatment of neurotrophic keratopathy.

We are doing this study to test the feasibility and acceptability of an experimental communication device. This device was invented by a team from the Duke Pratt School of Engineering and is intended to help people with dementia and their caregivers. We want to know if this tool can be used to help people with dementia who live at home with their families.

We are doing this study to find out if a study drug called ivosidenib is a safe and effective option for locally advanced or metastatic conventional chondrosarcoma with an isocitrate dehydrogenase 1 (IDH1) mutation.

In this study, people will take a medicine called S241656 by mouth. They may take it by itself or with other cancer treatments, and they may take it once or twice a day depending on their study group. The study has two parts. In Part 1, people receive different amounts of the medicine so researchers can find the safest dose. In Part 2, people receive the safest dose that was found in Part 1. Participants will keep taking the medicine until their cancer gets worse or the side effects become too strong or happen too often. During the study, they will visit the clinic regularly and have many tests, including blood tests, urine tests, and scans. The whole study is expected to last about five years.

In this study, participants will complete two or three in-person visits where they answer surveys and walk for six minutes. After that, they will be placed into one of two groups. One group will start the exercise and nutrition program right away, and the other group will start the program later. The program lasts for twelve weeks. During this time, there will be classes three times each week that last one hour. There will also be a nutrition session every other week. Participants do not need to attend every session, but they are asked to come to at least two thirds of the classes.

As part of the study, you'll get your regular CT scan, plus a few extra pictures just for the study. You'll also get an MRI, either on the same day or another day—whichever works best for you. On the same day as your MRI, you’ll also get an ultrasound. If you haven’t had a certain blood test called a hematocrit test in the last day, you’ll get a small blood test during your CT scan to check how healthy your liver is.