Clinical Trials Directory

431 clinical trials found.
Heart and Circulation

We are doing this study to learn more about the safety and performance of heart valve repair and replacement products made by Medtronic.

Compensation: No
Non-Oncology
Kidneys, Bladder and Urinary System

We are doing this study to keep tabs on the health status of people who have used, or who plan to use, a Medtronic® medical device to treat a urological or digestive disorder. This study is a registry, which means that it will allow us to compile information about how well these products work and how well they improve patients' quality of life.

Compensation: No
Ages: 18-110
Non-Oncology
Duke University Hospital, Duke Raleigh Hospital, Other
Gynecologic Cancer

We are doing this study to compare 2 different treatment options for endometrial intraepithelial neoplasia (EIN) in the uterus. We want to find out if the combination of metformin and megestrol acetate can decrease the growth of EIN better than megestrol on its own. We will compare how well both options work for women who are planning to either have a hysterectomy or have an intrauterine device (IUD) placed.

Compensation: Yes
Ages: 18-110
Oncology
Duke University Hospital, Duke Raleigh Hospital
Skin Cancer - Melanoma

We are doing this study to look at blood, tumor, and lymph node tissue from people with melanoma so we can improve diagnostic methods and therapies for people with melanoma.

Compensation: No
Oncology
Women's Health

We are doing this study to learn more about the symptoms of menopause in women with sickle cell disease (SCD). We want to learn more about how hydroxyurea, pain, and other SCD-related complications can affect their menopause experience. We hope this study can help us more quickly and easily find out when women with SCD might be experiencing health complications related to menopause.

Compensation: No
Ages: 35-110
Non-Oncology
Remote/online
Hematologic Malignancies and Cellular Therapy

We are doing this study to find the most effective, safe dose of an experimental drug called bomedemstat (the study drug) for people with essential thrombocythemia who are unable to take hydroxyurea or do not get a benefit from it.

Compensation: No
Oncology
Mental Health, Behavior, and Substance Abuse

We are doing this study to compare 2 different approaches to help people quit smoking. We want to know which of these approaches is most likely to help smokers who have a mental illness and want to stop smoking. We are doing this study in partnership with Wake Forest University, and study team members from Wake Forest are managing the enrollment for this study.

Compensation: Yes
Ages: 18-110
Non-Oncology
Remote/online
Digestive System

We are doing this study to find out if an experimental drug called volixibat (the study drug) is a safe and effective option for itching that is caused by primary sclerosing cholangitis (PSC).

Compensation: Yes
Ages: 18-110
Non-Oncology
Duke University Hospital