Clinical Trials Directory

426 clinical trials found.
Gastrointestinal Cancer

We are doing this study to find out if an experimental drug called ASP2138 (the study drug) is a safe and effective option for people with gastroesophageal junction (GEJ) cancer or metastatic pancreatic cancer.

Compensation: No
Oncology
Eyes and Vision

We are doing this study to find out if an experimental drug called RGX-314 (the study drug) is a safe and effective treatment for wet macular degeneration (WMD). RGX-314 is an experimental gene therapy drug that is designed to make people's bodies produce a protein that blocks the production of a bodily substance called vascular endothelial growth factor (VEGF). We want to know if this drug can continually block the production of VEGF, which might help prevent fluid build-up in the eye.

Compensation: Yes
Ages: 55-89
Non-Oncology
Duke University Hospital
Immune System and Infections

We are doing this study to find out if an experimental drug called efzofitimod (the study drug) is a safe and effective option for people with SSc-ILD. We want to know how well the study drug works against the skin and lung effects caused by SSc-ILD.

Compensation: Yes
Ages: 18-110
Non-Oncology
Duke University Hospital
Skin Cancer - Melanoma

We are doing this study to find out if a study drug called belzupacap sarotalocan (bel-sar) is a safe and effective option when it is combined with laser light therapy for people who have a type of eye cancer called an indeterminate lesion (a growth in your eye that is suspected to be melanoma) or choroidal melanoma, which is also known as eye melanoma.

Compensation: Yes
Ages: 18-110
Oncology
Duke University Hospital
Gastrointestinal Cancer

We are doing this study to compare 2 different regimens for treating pancreatic cancer after surgery. We what find out how well patients do after they get a combination of the drugs cevumeran, atezolizumab, and mFOLFIRINOX compared to just getting mFOLFIRINOX alone. Cevumeran is an experimental drug that is made from your own cells that are obtained from blood and tissue samples. It is designed to activate your immune system against cancer cells in your body.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Endocrine and Metabolic System

We are doing this study to find out if an experimental drug called avexitide (the study drug) is a safe and effective option to prevent or reduce the severity of hypoglycemia episodes for people who have post-bariatric hypoglycemia following Roux-en-Y gastric bypass.

Compensation: Yes
Ages: 18-110
Non-Oncology
Duke Regional Hospital, Duke Raleigh Hospital
Breast Cancer

We are doing this study to find out if a program called AYA STEPS has a positive benefit for young people who are treated for cancer. We want to know how well this program can help cancer survivors younger than 40 manage any physical or emotional symptoms they have after treatment, and we also want to see if the program can help them be more engaged with follow-up care.

Compensation: Yes
Ages: 18-39
Oncology
Remote/online
Pregnancy Concerns

We are doing this study promote the importance of quitting smoking for pregnant women and to improve how providers can help their patients quit smoking.

Compensation: Yes
Ages: 18-110
Non-Oncology
Duke University Hospital, Other