Clinical Trials Directory

387 clinical trials found.
Brain and Spine Metastasis

We are doing this study to find out if an experimental drug called APL-5125 (the study drug) is a safe and effective for people with select types of gastrointestinal cancer. We are also trying to find the best dose of APL-5125 to use.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Transplant Medicine

We are doing this study to see if people have the L1 gene called apolipoprotein (APOL1) and to learn how this may affect them.

Compensation: No
Non-Oncology
Heart and Circulation

We are doing this study to learn more about the safety and effectiveness of the Medtronic Intrepid Transcatheter Mitral Valve Replacement System.   

Compensation: Yes
Ages: 18-110
Non-Oncology
Duke University Hospital
Gastrointestinal Cancer

We are doing this study to see if the study drugs, domvanalimab and zimberelimab, are safe and effective for treating advanced or metastatic gastroesophageal adenocarcinoma.

Compensation: Yes
Ages: 18-110
Oncology
Duke University Hospital
Heart and Circulation

We are doing this study to determine the safety and effectiveness of an experimental medical device called the GORE Ascending Stent Graft (ASG Device) for the treatment of aortic diseases.

Compensation: No
Non-Oncology
Skin Cancer - Melanoma

We are doing this study to learn more about the effects of an experimental drug called RP1 (the study drug) for organ transplant recipients who have an advanced form of skin cancer.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Breast Cancer

We are doing this study to find out if a study drug called sacituzumab govitecan can improve outcomes for patients with high risk, early triple negative breast cancer (TNBC). We want to know if giving this drug in combination with pembrolizumab will work better than pembrolizumab on its own or better than pembrolizumab + capecitabine.

Compensation: No
Oncology
Brain, Spinal Cord and Nerves

We are doing this study to compare 2 different options for preventing strokes for people who have atrial fibrillation. We want to find out if apixaban or aspirin is the better choice to help prevent future strokes for patients with atrial fibrillation and who had a recent brain hemorrhage.

Compensation: Yes
Ages: 18-110
Non-Oncology
Duke University Hospital