Clinical Trials Directory

324 clinical trials found.
Cancer Immunotherapy

We are doing this study to find out if the combination of 2 experimental drugs called C-TIL051 and NKTR-255 when they are given along with pembrolizumab is a safe and effective option for non-small cell lung cancer (NSCLC). C-TIL051 is custom-made for each participant from their own tumor tissue. Immune cells are isolated from your tumor tissue, regrown in a lab, and then formulated to be returned to your bloodstream. We want to know if C-TIL051 can help people's immune systems target and destroy cancer cells. NKTR-255 is designed to help C-TIL051 work better.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Radiation Oncology

We are doing this study to collect information about people with oligometastasis for future use.

Compensation: No
Ages: 18-110
Oncology
Remote/online
Radiation Oncology

We are doing this study to understand the benefit of using PET scan in addition to the standard of care CT scan to plan for radiation therapy. The PET-CT scan may allow your radiation doctor to fine tune the radiation plan or the delivery of radiation to your cancer.

Compensation: No
Ages: 18-100
Oncology
Duke University Hospital
Older Adults/Aging

We are doing this study to learn more about Alzheimer's disease and other illnesses of aging (e.g., dementia, mild cognitive impairment [MCI], or other cognition disorders).

Compensation: Yes
Ages: 25-80
Non-Oncology
Duke University Hospital
Lungs and Breathing

We are doing this study to find out if L-citrulline (the study drug) will help improve asthma symptoms when taken daily. This study is important because managing symptoms of asthma can improve quality of life and long-term health.

Compensation: Yes
Ages: 18-65
Non-Oncology
Other
Gynecologic Cancer

We are doing this study to find out if certain experimental drug combinations are safe and effective options for people who have recurrent or persistent endometrial cancer (cancer that has come back after treatment or does not respond to treatment).

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Pediatric Cancer

We are doing this study to find out if carefully watching patients with low risk germ cell tumors after surgery will have different results than treating people with chemotherapy afer their surgery.

For people who are in standard risk groups related to germ cell tumors, we want to compare the effects of carboplatin with cisplatin and find out which of these drugs seems to work better.

Compensation: No
Oncology
Older Adults/Aging

We are doing this study to help us identify the underlying causes of brain disorders such as delirium and/or dementia.

Compensation: No
Non-Oncology