Clinical Trials Directory

324 clinical trials found.
Eyes and Vision

We are doing this study to find out if an experimental drug called RGX-314 (the study drug) is a safe and effective treatment for wet macular degeneration (WMD). RGX-314 is an experimental gene therapy drug that is designed to make people's bodies produce a protein that blocks the production of a bodily substance called vascular endothelial growth factor (VEGF). We want to know if this drug can continually block the production of VEGF, which might help prevent fluid build-up in the eye.

Compensation: Yes
Ages: 55-89
Non-Oncology
Duke University Hospital

We are doing this study to compare 2 different regimens for treating pancreatic cancer after surgery. We what find out how well patients do after they get a combination of the drugs cevumeran, atezolizumab, and mFOLFIRINOX compared to just getting mFOLFIRINOX alone. Cevumeran is an experimental drug that is made from your own cells that are obtained from blood and tissue samples. It is designed to activate your immune system against cancer cells in your body.

Compensation: No
Ages: 18-110
Duke University Hospital
Other

We are doing this study to learn more about benralizumab and evaluate its potential effect in treatment for patients with hypereosinophilic syndrome (HES).

Compensation: No
Non-Oncology
Pregnancy Concerns

We are doing this study promote the importance of quitting smoking for pregnant women and to improve how providers can help their patients quit smoking.

Compensation: No
Non-Oncology
Eyes and Vision

We are doing this study to find out if pictures taken of the back of the eye (retina) using a special type of camera called Optical Coherence Tomography (OCT) can predict how well a baby will be able to see and how their brain works at school age.

El propósito de este estudio es determinar si las fotos tomadas del fondo de ojo (retina) usando una cámara especial que se llama Tomografía de coherencia Óptica (OCT), puede predecir la visión y como el cerebro funciona a la edad escolar.

Compensation: Yes
Ages: 0-50
Non-Oncology
Duke University Hospital
Skin Cancer - Melanoma

We are doing this study to find out if an experimental drug called MK-4280A (the study drug) is a safe and effective option for people who are diagnosed with different types of solid tumors. We are enrolling Arm A of this study, which is open to people diagnosed with cutaneous squamous cell carcinoma (cSCC).

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital, Duke Raleigh Hospital
Hematologic Malignancies and Cellular Therapy

We are doing this study to find out if an investigational drug called TP-3654 (the study drug) is a safe and effective treatment for myelofibrosis. The study drug will be tested at different doses to find out what effects, if any, it has on myelofibrosis.

Compensation: No
Oncology

We are doing this study to monitor the health of the cornea in participants with neovascular age-related macular degeneration (nAMD), also know as wet AMD, who receive an eye implant that continuously delivers the drug ranibizumab into the back of the eye.

Compensation: Yes
Ages: 55-89
Duke University Hospital