Clinical Trials Directory

469 clinical trials found.
Cancer Immunotherapy

We are doing this research study to learn about the safety and effectiveness of alirocumab (a cholesterol-lowering drug) when it is combined with cemiplimab (an immunotherapy drug) and preoperative chemotherapy in patients with stage 1B-3A non-small cell lung cancer (NSCLC) who will undergo surgery. This study is important because it might potentially improve outcomes for you and other future patients.

Compensation: No
Oncology
Gynecologic Cancer

We are doing this study to find out if an experimental drug called TORL-1-23 (the study drug) is a safe and effective option for women who have advanced ovarian cancer, primary peritoneal, or fallopian tube cancer.

Compensation: No
Ages: 18-110
Oncology
Duke Raleigh Hospital

In the TRANSFORM study, the team will check your medical history and medicines. They will measure your height, weight, blood pressure, and waist size. If your recent lab results are not in your records, they will take a blood sample to check things like cholesterol, blood sugar, liver and kidney health, and inflammation. You will get these results. Another blood sample will be saved for future research to learn more about heart disease and your DNA, but you will not get those results. If your numbers are in the right range, you will have a special heart scan called a coronary CT.

Compensation: Yes
Ages: 3-5
Duke University Hospital, Pickett Road Research
Women's Health

We are doing this study to help women regain bladder strength and function after having their first baby. We want to find out which treatment options work best to stop bladder leakage.

Compensation: Yes
Ages: 18-110
Non-Oncology
Duke University Hospital, Duke Regional Hospital, Duke Raleigh Hospital, Other
Bones, Joints and Muscles

We are doing this study to get a better understanding of why people are at higher risk of developing arthritis after ACL reconstruction surgery. We hope the information from this study can help improve recovery techniques and lower the risk of developing knee arthritis for people who have ACL surgery. We are partnering with UNC-Chapel Hill to do this study.

Compensation: Yes
Ages: 18-50
Non-Oncology
Duke University Hospital, Other
Hematologic Malignancies and Cellular Therapy

We are doing this study to evaluate the safety and effectiveness of a drug called isatuximab when it is used in combination with lenalidomide and dexamethasone at lower doses. We want to know if this low dose combination can help patients with multiple myeloma achieve a better response while causing fewer or less severe side effects.

Compensation: No
Oncology
Eyes and Vision

We are doing this study to learn more about variants in people's genes that cause cells in the back of the eye to function incorrectly and lead to a process called "retinal degeneration."

Compensation: Yes
Ages: 4-110
Non-Oncology
Duke University Hospital

The goal of this study is to learn more about how certain hormones and cells in the pancreas help keep blood sugar at a healthy level. This is very important when the body does not respond well to insulin, which can happen with obesity and diabetes. By doing this study, researchers hope to find better ways to care for and treat diabetes.

Compensation: Yes
Ages: 18-45
Other