Clinical Trials Directory

276 clinical trials found.
Ear, Nose and Throat

We are doing this study to find out if a brain stimulation technique called transcranial direct current stimulation (tDCS) is beneficial for people with a cochlear implant (CI) when it is combined with home-based auditory training. We want to see if there are any improvements in speech perception performance after a 4-week training period for people with CIs.

Compensation: No
Ages: 50-90
Non-Oncology
Remote/online, Duke University Hospital
Primary Brain and Spinal Cord Tumors

We are doing this study to see if an experimental combination of drugs (D2C7-IT and 2141-V11) is a safe treatment for brain tumors.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital

We are doing this study to learn more about the use of the da Vinci Single-Port Surgical System in nipple-sparing mastectomy (NSM) procedures. We want to find out if the outcomes of NSM using this robotic-assisted technology are better than the current standard of open surgery.

Compensation: Yes
Ages: 21-110
Duke University Hospital
Gastrointestinal Cancer

We are doing this study to collect information about how well dabrafenib plus trametinib works in patients who have unresectable (cannot be removed by surgery) or metastatic BRAF V600E mutation positive solid tumors.

Compensation: No
Oncology
Skin Cancer - Melanoma

We are doing this study to find out if the combination of the drugs Dapansutrile and Pembrolizumab is a safe and effective treatment for people with melanoma that does not improve after PD-1 therapy.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Biobank / Biospecimen Collections

We are doing this study to collect and store information and samples that will be used for future research studies about transplants.

Compensation: No
Ages: 0-100
Non-Oncology
Duke University Hospital
Heart and Circulation

We are doing this study to collect and store your medical information and specimens for use in future research studies to understand heart function and disease.

Compensation: No
Non-Oncology
Infectious Diseases

If you choose to join this study, you will complete up to 10 study visits and 2 phone call check-ins over 72 weeks. This study includes:
- Pulmonary function tests (how well your lungs are working)
- CT scans of the chest (a special type of imaging that creates 3D X-ray images)
- Blood draws
- Questionnaires

During the study, you will be randomized (like flipping a coin) to get either:
- The study drug (Doxycycline) by mouth twice a day for 72 weeks; OR
- A placebo (sugar pill) by mouth twice a day for 72 weeks

Compensation: Yes
Ages: 30-110
Non-Oncology
Duke University Hospital