Clinical Trials Directory

487 clinical trials found.
Hematologic Malignancies and Cellular Therapy

We are doing this study to find out if patients with SAA who have not received previous treatment for this diagnosis can be treated safely and effectively with transplant as their first therapy.

Compensation: No
Ages: 3-75
Oncology
Duke University Hospital
Brain, Spinal Cord and Nerves

We created this healthy volunteer registry for people who would like to participate in brain imaging research studies. These studies use structural and functional MRI data to study areas of the brain associated with movement, memory, attention, and perception.

Compensation: Yes
Ages: 18-80
Non-Oncology
Duke University Hospital
Cancer Prevention and Screening

We are doing this study to better understand women's preferences for and concerns about hormone replacement. We want to learn from women who have had their fallopian tubes and ovaries removed due to BRCA1 and BRCA2 mutations.

Compensation: Yes
Ages: 19-49
Non-Oncology
Duke University Hospital
Breast Cancer

We are doing this study to try and find a way to detect breast cancer earlier or before it recurs.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Breast Cancer

This study has three parts: 1. Getting Ready (Screening) - Takes up to 28 days - You'll get blood tests, a tissue sample, a TB test, and health checkups like scans and heart tests. 2. Treatment (Study Dosing) - People are grouped by race - You'll be randomly picked to get either regular chemo or chemo plus a study medicine (tocilizumab) - Medicine is given every 4 weeks - You'll keep doing health checkups and answer questions. 3. After Treatment (Follow-up) - Happens within 30 days after your last dose - More health checkups and questions to see how you're doing.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital, Duke Raleigh Hospital
Breast Cancer

We are doing this study to collect breath samples to develop an experimental breath test that aims to detect breast cancer at its earliest stages. Additionally, we will look into whether a person's "breath signature" changes before and after they have undergone surgery for breast cancer.

Compensation: Yes
Ages: 40-74
Oncology
Duke University Hospital
Primary Brain and Spinal Cord Tumors

This study has three parts: 1. Screening Period (about 10 days): You will go to the clinic for tests like a brain scan (MRI), blood tests, heart check (EKG), and physical and brain exams. 2. Study Dosing Period: You will get a medicine called BRiTE through a small tube in your vein using a portable pump. It will run for 4 days. Then, you will not get any medicine for 24 days. This is called one cycle. You will go through 3 cycles like this. 3. Follow-Up Period: Doctors will keep checking on you with exams, blood tests, heart checks, and brain scans. You will visit the clinic every 8 weeks to make sure everything is going well.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Hematologic Malignancies and Cellular Therapy

In this study, people will take a medicine called R289 by mouth once or twice a day. The study has two parts: one part is to find the best dose, and the other part is to test two different doses. You may take the medicine at home or at the clinic. You will visit the clinic regularly for tests like blood work, physical check-ups, and heart exams. Some visits may take up to 8 hours. You can stay in the study as long as the medicine is helping and the side effects are not too strong.

Compensation: No
Ages: 18-100
Oncology
Duke University Hospital