Clinical Trials Directory

We are doing this study to better understand how breast cancer treatment can affect the heart. In particular, we want to know if treatment with near complete estrogen deprivation (NCED) therapy has an impact on heart function.

We are doing this study to find out if an experimental drug called CTX131 (the study drug) is a safe and effective treatment for different forms of cancer with solid tumors. The study drug is made from white blood cells or T cells from healthy donors.

We are doing this study to find out if an experimental product called cryopreserved platelets (CPP) can help control the bleeding that happens during and after cardiopulmonary bypass surgery. We want to see how well this product works in comparison to the standard therapy that is used to control bleeding during surgery, which is liquid stored platelets (LSP).

We are doing this study to find out what effects (good or bad) the study device (RejuvenAir) may have on people with chronic bronchitis.

This device uses a cryospray (liquid nitrogen) that will go directly into the airways for the treatment of chronic bronchitis.

If you choose to join this study, you will:
- Be randomly assigned (like a coin flip) to 1 of 2 groups
-- One group will get the study drops
-- The other group will get a placebo (eye drops with no active medicine)

This study is blinded, so you will not know to which group you have been assigned. If you are assigned to receive the placebo, we will let you know at the end of the initial study period and you will have the option to receive the study drops if you want.

Depending on the eye drops you will receive, you will:
- Keep in touch with the study team between 2.5 and 5 months
- Visit our clinic at the Duke Eye Center between 10 and 20 times

At various visits, you will have blood draws, answer questionnaires, and have eye exams and vision tests.

We are doing this study to collect cerebrospinal fluid (CSF) samples from people with cancer that has spread to the leptomeninges (the inner membranes that cover the brain and spinal cord). These CSF samples will be used in laboratory research projects to identify substances called biomarkers. Biomarker testing is a way to look for genes, proteins, and other substances (tumor markers) that can provide information about cancer. Information from these CSF samples may help us learn about new methods to treat metastatic disease to the leptomeninges.

We are doing this research to learn more about whether taking a blood thinner, along with medications that prevent blood clots, improve outcomes in patients who develop atrial fibrillation (irregular heartbeat) after coronary artery bypass grafting surgery.

We are doing this study to compare treatment options for mitral valve regurgitation.