Clinical Trials Directory

442 clinical trials found.
Genitourinary Cancer

We are doing this study to find the most effective, safe dose of an experimental drug called pocenbrodib (the study drug). We want to see how it works when it is given by itself and also when it is given with other drugs already approved for the treatment in people with metastatic castration-resistant prostate cancer (mCRPC).

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Inpatient Studies

If you choose to join this study, you or your child, will:

  • Allow us access to your medical record for up to 5 years
  • Answer questions about your health history and current symptoms
  • Have a nasal swab
  • Give a stool sample
  • Complete 3 follow-up phone calls
  • Have blood drawn (only if in the hospital or l)

Compensation: No
Non-Oncology
Research for Healthy Adults

We are doing this study to learn more about how certain vaccines can affect people's polyethylene glycol (PEG) sensitivity levels. PEG is a component of several different vaccines. We want to compare blood samples from healthy volunteers to blood samples from HIV Vaccine Trials Network (HVTN) 133 participants. We hope this will help us better understand the variation of PEG sensitivity in the general population and between vaccinated and unvaccinated individuals.

Compensation: Yes
Ages: 18-50
Non-Oncology
Other
Gastrointestinal Cancer

We are doing this study to find out if pelvic floor physical therapy can improve sexual function for women who have undergone pelvic radiation.

Compensation: No
Ages: 19-110
Oncology
Remote/online
Brain and Spine Metastasis

We are doing this study to see if the study drug, dostarlimab, can reduce the recurrence of cancer in people who have had their colon cancer surgically removed.

Compensation: No
Oncology
Radiation Oncology

We are doing this study to understand whether people who receive a lower radiation dose after an interim (the second scan) PET-CT identifies an early treatment response have a similar outcome to those receiving a standard radiation dose. The results of the interim PET-CT scan will be used to guide your radiation dose plan. Depending on the PET-CT results, you will either receive a reduced radiation dose or the standard radiation dose for your cancer.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital, Duke Raleigh Hospital
Phase I

We are doing this study to find the most effective, safe dose of an experimental drug called PF-0793440 (the study drug). We want to know how well it works on its own and in combination with other drugs for the treatment of different cancers in people who have KRAS mutation(s).

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Hematologic Malignancies and Cellular Therapy

We are doing this study to find out if an experimental drug called navtemadlin (the study drug) is a safe and effective option for people with myelofibrosis (MF). We want to know how well it works when it is combined with ruxolitinib for people who did not get the desired results from ruxolitinib on its own.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital