Clinical Trials Directory

We are doing this study to test different combinations of ultrasound stimulation that might help restore arm strength for people dealing with arm weakness after a stroke. We want to find out which combination appears to have the most positive benefit for enhancing motor function and boosting brain activity.

If you decide to be part of the study, here's what will happen: - You'll get check-ups and blood tests. - Doctors will take pictures of your brain using special machines called CT or MRI. - Your heart will be checked with a test called an ECG. - You'll have a special treatment called Exablate to help medicine reach your brain better. You might get up to 6 rounds of treatment over about 15 weeks, but only if the doctors thinks it's safe to keep going.

We are doing this study to learn more about why the right side of the heart doesn't work well in certain heart conditions. We're using heart tissue samples from people with specific heart problems to help us make these important discoveries.

We are doing this study to collect blood and cerebrospinal fluid samples from patients who have breast cancer that has spread to the brain and/or spinal cord. We hope that by analyzing these samples, we can find out how effective different cancer medications are at treating metastases to the leptomeninges (tissue that surrounds the brain and spinal cord). We also want to do genetic testing on these samples to look for cancer mutations that can give us clues about how people might respond to different therapies or which therapies are most likely to be helpful.

This study has three parts called screening, treatment, and follow up. During screening, doctors will do tests to see if a person can join the study. If eligible, participants will be placed into one of two groups by chance. One group will take a medicine called rocbrutinib, and the other group will take a medicine called pirtobrutinib. Both medicines are taken by mouth once each day. During the study, participants will have regular clinic visits, blood tests, and scans to check their health and see how the cancer is responding. They can continue taking the study medicine as long as it is helping and side effects are manageable. After treatment ends, doctors will continue to check on participants for several years through follow up visits and phone calls.