Clinical Trials Directory

432 clinical trials found.
Brain, Spinal Cord and Nerves

We are doing this study to learn more about the rare diagnosis of New Daily Persistent Headache (NDPH). We want to get more information about why some children and young people develop this condition and how it is different from traditional headaches, like migraines. This knowledge can help us to begin developing possible treatments for NDPH.

Compensation: No
Ages: 12-18
Non-Oncology
Duke University Hospital
Skin Cancer - Melanoma

We are doing this study to find out if an investigational called Daromun (the study drug) is a safe and effective treatment for melanoma. We want to know if treating people with the drug before surgery to remove tumors can lower the chance of cancer recurrence.

Compensation: Yes
Ages: 18-110
Oncology
Duke University Hospital
Endocrine and Metabolic System

We are doing this study to learn more about the following symptoms that can be related to primary hyperparathyroidism: confusion, difficulty remembering and focusing, memory fog, changes in a person's normal behavior, feeling "blue", increased anxiety, increased agitation, and trouble performing daily activities, like driving and remembering appointments. We want to know how much these symptoms change in older adults after they have endocrine surgery.

Compensation: No
Ages: 65-110
Non-Oncology
Duke University Hospital
Mental Health, Behavior, and Substance Abuse

We are doing this study to find out if combining psychological skills and a procedure called neurostimulation during one clinic session can help reduce negative emotions and problems with dealing with emotions in both a laboratory setting and in a person's everyday life.

Compensation: Yes
Ages: 18-55
Non-Oncology
Duke University Hospital
Primary Brain and Spinal Cord Tumors

We are doing this study to find out if an investigational drug called NMS-0330593 (the study drug) is safe and effective option when it is given in combination with temozolomide (an approved drug for the treatment of diffuse glioma). We want to know if this drug combination works better than temozolomide on its own.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Brain, Spinal Cord and Nerves

We are doing this study to collect information about the speeds of eye and head movements in healthy children and young adults. This information will help us establish normal values related to these movement speeds and patterns. If we have a measure of what is normal, this will help us determine the severity of symptoms or injury for people who are treated for concussions.

Compensation: Yes
Ages: 12-25
Non-Oncology
Duke University Hospital, Duke Regional Hospital, Duke Raleigh Hospital, Pickett Road Research, Other
Digestive System

We are doing this study to find out if an experimental drug called NST-6179 (the study drug) is a a safe and effective option for patients with intestinal failure-associated liver disease (IFALD).

Compensation: Yes
Ages: 18-110
Non-Oncology
Duke University Hospital
Breast Cancer

We are doing this study to compare two commonly used treatment choices for early-stage breast cancer in premenopausal women. We want to know if either option is a better choice than the other.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital, Duke Raleigh Hospital, Other