Clinical Trials Directory

473 clinical trials found.
Biobank / Biospecimen Collections

We are doing this study to identify new signs and symptoms of inflammatory bowel disease (IBD) in children and young adults. We want to improve at predicting the future course of IBD so that we can treat it better and faster. We also hope this study will help us learn how IBD develops so that we can make new treatments for IBD.

Compensation: Yes
Ages: 2-21
Non-Oncology
Duke University Hospital
Biobank / Biospecimen Collections

We are doing this study to find out if nighttime dosing of a sedative called dexmedetomidine (the study drug) can reduce the occurrence of delirium (a state of mental confusion) in older adults who have heart surgery.

Compensation: Yes
Ages: 60-110
Non-Oncology
Duke University Hospital

This study wants to see if a medicine called minoxidil can help people heal better after breast reconstruction surgery. Minoxidil is already approved by the FDA and may work by helping more blood flow to the skin. Everyone in the study will get two solutions before surgery. One solution has the medicine and the other does not. One will be put on one breast and the other on the other breast. Neither the patient nor the doctor will know which is which. The solutions will be used every day for two weeks before surgery. After surgery, the study team will check how well the healing went to see if the medicine made a difference.

Compensation: No
Ages: 18-110
Duke University Hospital
Mental Health, Behavior, and Substance Abuse

We are doing this study to learn more about how well a study intervention works to reduce distress caused by misophonia. This intervention combines neurostimulation and skills-based training that is designed to help people think differently.

Compensation: Yes
Ages: 18-55
Non-Oncology
Duke University Hospital
Hematologic Malignancies and Cellular Therapy

We are doing this study to find the most effective, safe dose of an experimental drug called bomedemstat or hydroxyurea in people with essential thrombocythemia (ET). We also want to know which of these options works best for most people.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Hematologic Malignancies and Cellular Therapy

We are doing this study to find out if adding a drug called enasidenib (the study drug) to the standard treatment for myelodysplastic syndrome (MDS) can improve the likelihood of achieving complete remission. The study drug is approved for acute myeloid leukemia (AML), but is not approved for the treatment of MDS.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Primary Brain and Spinal Cord Tumors

We are doing this study to find out if giving patients a drug called atezolizumab before and after surgery for recurrent glioblastoma can improve how their cancer responds.

Compensation: No
Oncology