Clinical Trials Directory

433 clinical trials found.
Phase I

We are doing this study to find the most effective, safe dose of an experimental drug called PF-0793440 (the study drug). We want to know how well it works on its own and in combination with other drugs for the treatment of different cancers in people who have KRAS mutation(s).

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Hematologic Malignancies and Cellular Therapy

We are doing this study to find out if an experimental drug called navtemadlin (the study drug) is a safe and effective option for people with myelofibrosis (MF). We want to know how well it works when it is combined with ruxolitinib for people who did not get the desired results from ruxolitinib on its own.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Hematologic Malignancies and Cellular Therapy

We are doing this study to find the most effective, safe dose of an experimental drug called CLN-049 (the study drug) for people with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS).

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Breast Cancer

We are doing this study to find out if an experimental drug called SRG-514 (the study drug) is a safe and effective option for breast cancer patients. We want to know if it can reduce the inflammation caused by surgery and allow your body to better heal itself and prevent tumor recurrence. We will also be trying to figure out the best dose of the drug to use.

Compensation: Yes
Ages: 18-110
Oncology
Duke University Hospital
Cancer Immunotherapy

We are doing this study to find out if an experimental drug called ADI-270 (the study drug) is a safe and effective option for patients with clear cell renal cell carcinoma that has come back after treatment or is not responding to treatment.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Hematologic Malignancies and Cellular Therapy

We are doing this study to find the most effective, safe dose of an experimental drug called GC012F (the study drug) for adults who have relapsed/refractory multiple myeloma.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Genitourinary Cancer

We are doing this study to find the most effective, safe dose of an experimental drug called V940 (the study drug) when it is given with pembrolizumab to people who have had surgery to remove their bladder, kidney, or other organs for muscle-invasive urothelial carcinoma. We want to know how well this combination works compared to taking pembrolizumab on its own.

Compensation: No
Oncology
Primary Brain and Spinal Cord Tumors

We are doing this study to find out if the experimental combination and use of the drugs nivolumab and relatlimab can provide a benefit for people who are newly diagnosed with isocitrate dehydrogenase (IDH) wildtype glioblastoma (ndGBM).

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital