Clinical Trials Directory

436 clinical trials found.
Trauma and Emergency Department Studies

We are doing this study to find out if an experimental drug called DefenCath® (the study drug) is a safe and effective means to lower the risk of central line infections for people who need total parenteral nutrition (TPN). TPN is when people get their necessary nutrients through a catheter in a vein because they are unable to properly digest food for nutrition. We want to know how well the study drug works compared to heparin catheter lock solution, which is the current option to help prevent infections.

Compensation: Yes
Ages: 18-110
Non-Oncology
Duke University Hospital, Pickett Road Research
Thoracic Cancer

We are doing this study to find the most effective, safe dose of an experimental drug called NVL-655 (the study drug). We want to know how well the study drug works compared to alectinib, which is a standard treatment for NSCLC.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital, Duke Raleigh Hospital
Hematologic Malignancies and Cellular Therapy

We are doing this study to find the most effective, safe dose of an experimental drug called NXC-201 (the study drug) for people with relapsed/refractory immunoglobulin light chain (AL) amyloidosis. The study drug is a CAR-T (chimeric antigen receptor) drug.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Bones, Joints and Muscles

We are doing this study to find out which type of surgery has the best outcomes for people who have shoulder dislocations with bone loss. There are 3 types of surgeries that doctors can perform to stabilize the shoulder of people who have this type of injury, but there is no evidence at this time that proves one is better than the others. We hope this study can help us figure out how to choose the best option for different patients. This is an observational study and participation will not affect the treatment option you choose to pursue.

Compensation: Yes
Ages: 18-50
Non-Oncology
Other
Eyes and Vision

We are doing this study to find out if an experimental gene transfer drug called OCU410ST is a safe and effective option for Stargardt Disease (STGD).

Compensation: Yes
Ages: 6-75
Non-Oncology
Duke University Hospital
Genitourinary Cancer

Compensation: No
Oncology
Head and Neck Cancer

We are doing this study to learn more about the olfactory receptor expression (which give us our sense of smell) and neurogenesis (creation of cells) in human olfactory tissue.

Compensation: No
Oncology
Breast Cancer

We are doing this study to improve how cancer patients and their providers communicate with each other. We want to know how personal biases can affect how cancer care is explained and managed. We think being able to identify bias if any exists can improve care and patients' psychological well-being.

Compensation: Yes
Ages: 21-110
Oncology
Duke University Hospital, Duke Raleigh Hospital, Other