Clinical Trials Directory

We are doing this study to find out if the combination of an experimental drug called ONC201 (the study drug) with paxalisib is an effective option for patients with a diffuse midline glioma (DMG). We also want to see how much of these drugs are absorbed by tumor tissue in patients with brain tumors.

We are doing this study to gather information on Stargardt Disease Type 1 (STGD1) and how it develops over time.

We are doing this study to find out if an experimental drug called ADI-PEG 20 (the study drug) combined with two types of FDA-approved chemotherapies (gemcitabine and docetaxel) is a safe and effective option for people who have leiomyosarcoma.

We are doing this study to find out if an experimental drug called BBI-355 (the study drug) is a safe and effective option for people with solid tumor forms of cancer. We also want to know the best dosing strategy for the drug. We plan to have later parts of this study that will look at how the study drug works when it is given with other cancer drugs.

We are doing this study to find out if adding azithromycin to the routine single antibiotic preventative therapy can lower the risk of developing infections after a cesarean delivery.

We are doing this study to learn more about how 2 different classes of diabetes medications help lower the risk of heart disease. The types of diabetes medications that have been shown to reduce the risk of new or worsening heart disease are SGLT2 inhibitors and GLP-1 receptor agonists. We don't know which of these drugs might be preferable to reduce heart disease risk for diabetes patients, and we hope this study can help us find out which drug(s) may be the most appropriate for most patients.

We are doing this study to find out if we can identify biomarkers that indicate the presence of ovarian cancer or indicate that it is likely to develop. Biomarkers are substances that can be released from cancer cells into the blood and can provide information on the following things: changes to someone's genes or DNA, how cancer cells will respond to cancer treatment, and whether cells are becoming resistant (no longer responding) to cancer treatment.

We are doing this study to find out whether it is possible to use genetic information from your tumor sample in order to test if your tumor will be sensitive to oxaliplatin (the standard of care treatment for your disease).