Clinical Trials Directory

392 clinical trials found.
Hematologic Malignancies and Cellular Therapy

We are doing this study to find out if either of two experimental drugs (mosunetuzumab and polatuzumab vedotin) is a safe and effective option for people who have had CAR T-cell therapy. We want to know how each drug works on its own as well as in combination with each other when given after CAR T-cell therapy is complete.

Compensation: No
Oncology
Genitourinary Cancer

We are doing this study to compare two treatment options for PRCC. We want to know if adding an experimental drug called atezolimumab (the study drug) to the typical drug used in PRCC treatment, cabozantinib, can improve outcomes or extend survival time.

Compensation: No
Oncology
Thoracic Cancer

We are doing this study to find out if a pair of investigational drugs called ramucirumab and pembrolizumab (the study drugs) are a safe and effective treatment for your form of cancer. We want to know how well the study drugs work in comparison to the standard treatment for Stage IV or recurrent NSCLC.

Compensation: No
Oncology
Eyes and Vision

We are doing this study to find out the effects, good or bad, of an investigational drug called RO7200220 (the study drug) for participants with uveitic macular edema. This condition is caused by uveitis, and it is when fluid builds up in the retinal layers and causes swelling that can impair vision.

Compensation: Yes
Ages: 18-110
Non-Oncology
Duke University Hospital
Biobank / Biospecimen Collections

We are doing this study to look at different tissues that could contribute to chronic pain and obesity.

Compensation: No
Ages: 18-80
Non-Oncology
Duke Regional Hospital
Surgery and Rehabilitation

We are doing this study to collect data and samples to store them for future research.

We hope the data and samples will lead to improved treatment of patients who are seriously ill or have been injured.

Compensation: No
Ages: 18-90
Non-Oncology
Duke University Hospital
Blood Disorders

We are doing this to see the effects of giving long-term red blood cell exchange transfusion to patients with sickle cell disease (SCD). We want to know if exchange blood transfusion may help with serious complications of SCD or reduce the chances of a new, serious problem happening.

Compensation: Yes
Ages: 18-110
Non-Oncology
Duke University Hospital
Hematologic Malignancies and Cellular Therapy

We are doing this study to find the most effective, safe dose of an experimental drug called SGR-1505 (the study drug). We want to know how well this study drug specifically targets a protein related to your B-cell cancer.

Compensation: No
Oncology