Clinical Trials Directory
People in this study will be put into different groups by chance, like picking straws. The groups will get different treatments: - Some will get a medicine called ONL1204 in small or larger amounts every 12 or 24 weeks. - Some will get pretend shots (called sham injections) every 12 or 24 weeks. - Some will get a different medicine called avacincaptad pegol about once every 28 days. There is a little more than a 50% chance of getting ONL1204, about an 18% chance of getting the pretend shots, and about a 27% chance of getting avacincaptad pegol. The study will last about 76 weeks. During that time, people will need to visit the clinic at least 8 times. They will have tests and check-ups that are part of regular care and also for the study.
We are doing this study to compare activity in the brains of female adults who have chronic pain and/or use opioids to the brain activity of healthy female adults who are pain-free. We hope this study can help us develop new and targeted treatments for adults with chronic pain and alternatives to opioid therapy.
This study will last about 8 weeks, but the time can change based on your schedule. People in the study will smoke special cigarettes instead of their usual ones. These cigarettes will have either a normal amount of nicotine or a very low amount. Which type you get will be random, like flipping a coin. Participants will have several visits: a remote screening (2 hours), an in-person screening (1 hour), two sessions after not smoking for 24 hours (90 minutes each), and five weekly visits (60–90 minutes each). There is also an optional part with four visits over 12 weeks to help quit smoking.
We are doing this study to find out if non-opioid means of pain relief are adequate for children who need mechanical ventilation for the treatment of acute respiratory failure. We want to know if acetaminophen and/or ketorolac can help provide enough relief to lower the need for using opioids to treat pain. Opioid pain medications have side effects (e.g., withdrawal symptoms and delirium) that can potentially be lessened if the study drugs are shown to provide an acceptable benefit.
We are doing this study to find out what pain management options work best for most children who have surgery to remove their tonsils (tonsillectomy). We will compare the outcomes of using fentanyl (a short-acting opioid) versus using methadone (a long-acting opioid) to control pain during and after surgery. Both drugs are commonly used for this purpose, but we don't have enough data to know which is the best option to reduce pain.
We are doing this study to find out what strategy after surgery has the best outcomes for patients with triple-negative breast cancer who have a complete response to chemotherapy before their surgeries. We want to compare 27 weeks of treatment with pembrolizumab after surgery to 27 weeks of monitoring without drug treatment and find out if there is a difference in terms of risk of having the cancer come back.
We are doing this study to find out if an experimental drug called ORIC-114 (the study drug) is a safe and effective option for possible treatment in patients with advanced solid tumors harboring an EGFR or HER2 alteration.
This study will happen during a child’s visit to the emergency room. There will be no extra visits after this. A doctor will first check the ears like normal and share their opinion. Then the doctor will use the Novoscope. The tip of the Novoscope will go into the outer ear, just like a regular ear check. The eardrum will get a soft puff of air, and the doctor will record an ultrasound reading. Collecting readings takes only 1 to 2 minutes for each ear. The whole study will take about 20 to 30 minutes. The study is very safe. The risks are no greater than a regular ear exam.