Clinical Trials Directory

324 clinical trials found.
Vaccine

We are doing this study to see if there is any difference in the safety and effectiveness of flu and COVID-19 vaccines if they are given at the same time or 1-2 weeks apart.

Compensation: Yes
Ages: 18-110
Non-Oncology
Other
Blood Disorders

We are doing this study to find out if a new type of assessment works well for middle-aged and older adults with sickle cell disease (SCD). We want to see if this assessment is useful in detecting changes in health. We hope the assessment can provide useful information to help improve the quality of life for adults with sickle cell disease.

Compensation: Yes
Ages: 40-110
Non-Oncology
Duke University Hospital
Breast Cancer

We are doing this study to find out if an experimental drug called lasofoxifene (the study drug) is a safe and effective option for breast cancer. We want to see if the study drug combined with another drug called abemaciclib has better results than treatment with abemaciclib plus fulvestrant.

Compensation: Yes
Ages: 18-89
Oncology
Duke University Hospital, Duke Raleigh Hospital
Brain and Spine Metastasis

We are doing this study to find out the highest dose of a drug called olaparib that is safe to give at
the same time as stereotactic radiosurgery (SRS). We also want to see if we can lessen the chance of having your cancer return by following the olaparib + SRS treatment with a combination of chemotherapy and a drug called durvalumab.

Compensation: No
Oncology
Bones, Joints and Muscles

We are doing this study to figure out the best approaches for treating knee injuries that involve more than one ligament. There are 2 primary goals of this study. In Aim 1 of the study, we want to find out if it is better to have surgery shortly after MLKI or if it is better to delay surgery. In Aim 2 of the study, we want to find out if it is better to start physical rehabilitation shortly after surgery or if it is better to delay rehabilitation for a few weeks.

Compensation: Yes
Non-Oncology
Duke University Hospital, Other
Immune System and Infections

We are doing this study to find out how common it is for people who have HIV to accumulate excess fat in the liver or develop steatotic liver disease.

Compensation: Yes
Ages: 18-110
Non-Oncology
Duke University Hospital
Brain and Spine Metastasis

We are doing this study to find out if an investigational drug called XL092 (the study drug) is a safe and effective option on its own or in combination with other anticancer drugs.

Compensation: No
Oncology
COVID-19

We are doing this study to find out if an investigational drug called abatacept (the study drug) is an effective option when it is given along with the current standard treatment for COVID-19.

Compensation: Yes
Ages: 18-100
Non-Oncology
Duke University Hospital, Duke Regional Hospital, Duke Raleigh Hospital, Pickett Road Research