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471 clinical trials found.
Kidneys, Bladder and Urinary System

We are doing this study to keep tabs on the health status of people who have used, or who plan to use, a Medtronic® medical device to treat a urological or digestive disorder. This study is a registry, which means that it will allow us to compile information about how well these products work and how well they improve patients' quality of life.

Compensation: No
Ages: 18-110
Non-Oncology
Duke University Hospital, Duke Raleigh Hospital, Other
Skin Cancer - Melanoma

We are doing this study to look at blood, tumor, and lymph node tissue from people with melanoma so we can improve diagnostic methods and therapies for people with melanoma.

Compensation: No
Oncology
Women's Health

We are doing this study to learn more about the symptoms of menopause in women with sickle cell disease (SCD). We want to learn more about how hydroxyurea, pain, and other SCD-related complications can affect their menopause experience. We hope this study can help us more quickly and easily find out when women with SCD might be experiencing health complications related to menopause.

Compensation: No
Ages: 35-110
Non-Oncology
Remote/online
Hematologic Malignancies and Cellular Therapy

We are doing this study to find the most effective, safe dose of an experimental drug called bomedemstat (the study drug) for people with essential thrombocythemia who are unable to take hydroxyurea or do not get a benefit from it.

Compensation: No
Oncology
Head and Neck Cancer

We are doing this study to find the most effective, safe dose of an experimental drug called petosemtamab (the study drug). We also want to know how well it works compared to the standard treatments used for metastatic/recurrent head and neck squamous cell carcinoma (HNSCC).

Compensation: No
Oncology
Digestive System

We are doing this study to identify new signs and symptoms of inflammatory bowel disease (IBD) in children and young adults. We want to improve at predicting the future course of IBD so that we can treat it better and faster. We also hope this study will help us learn how IBD develops so that we can make new treatments for IBD.

Compensation: Yes
Ages: 2-21
Non-Oncology
Duke University Hospital
Biobank / Biospecimen Collections

We are doing this study to find out if nighttime dosing of a sedative called dexmedetomidine (the study drug) can reduce the occurrence of delirium (a state of mental confusion) in older adults who have heart surgery.

Compensation: Yes
Ages: 60-110
Non-Oncology
Duke University Hospital

This study wants to see if a medicine called minoxidil can help people heal better after breast reconstruction surgery. Minoxidil is already approved by the FDA and may work by helping more blood flow to the skin. Everyone in the study will get two solutions before surgery. One solution has the medicine and the other does not. One will be put on one breast and the other on the other breast. Neither the patient nor the doctor will know which is which. The solutions will be used every day for two weeks before surgery. After surgery, the study team will check how well the healing went to see if the medicine made a difference.

Compensation: No
Ages: 18-110
Duke University Hospital