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403 clinical trials found.
Infectious Diseases

We are doing this study to find out if an investigational drug called ensitrelvir (the study drug) is an effective option when it is given along with the current standard treatment for COVID-19.

Compensation: No
Ages: 18-100
Non-Oncology
Duke University Hospital, Duke Regional Hospital, Duke Raleigh Hospital, Pickett Road Research
Heart and Circulation

We are doing this to study to test how well an investigational technology called the Endospan NEXUS Aortic Arch Stent Graft System (the study device) performs in the treatment of aortic arch disease.

Compensation: No
Non-Oncology
Breast Cancer

We are doing this study to find the safest and most effective dose of an experimental drug called Dato-DXd (the study drug) in patients with triple negative breast cancer (TNBC) and HER2-negative breast cancer.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Brain and Spine Metastasis

We are doing this study to find out if an investigational drug called TYRA-300 (the study drug) is a safe and effective option for patients with locally advanced/metastatic urothelial cancer and other solid tumors.

Compensation: No
Oncology
Women's Health

We are doing this study to learn more about the causes of unsuccessful pregnancies. We want to compare samples of endometrial tissue from women who have experienced infertility with samples from women who have had children without fertility treatment. We hope this can help improve future options for women who are having difficulty with pregnancy.

Compensation: Yes
Ages: 18-42
Non-Oncology
Other
Bones, Joints and Muscles

We are doing this study to get a better understanding of why people are at higher risk of developing arthritis after ACL reconstruction surgery. We hope the information from this study can help improve recovery techniques and lower the risk of developing knee arthritis for people who have ACL surgery. We are partnering with UNC-Chapel Hill to do this study.

Compensation: Yes
Ages: 18-50
Non-Oncology
Duke University Hospital, Other

We are doing this study to evaluate the safety and effectiveness of a drug called isatuximab when it is used in combination with lenalidomide and dexamethasone at lower doses. We want to know if this low dose combination can help patients with multiple myeloma achieve a better response while causing fewer or less severe side effects.

Compensation: No
Cancer Prevention and Screening

We are doing this study to better understand the unmet sexual health concerns of young adult male cancer survivors.

Compensation: Yes
Ages: 18-39
Oncology
Remote/online