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438 clinical trials found.
Sarcoma

We are doing this study to find out if a study drug called ivosidenib is a safe and effective option for locally advanced or metastatic conventional chondrosarcoma with an isocitrate dehydrogenase 1 (IDH1) mutation.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Brain, Spinal Cord and Nerves

We are doing this study to learn more about the connection between the brain and leg muscles in people who have chronic stroke. We want to understand how this connection affects the walking abilities of chronic stroke patients so we can provide better help to stroke patients who need to improve their motor function.

Compensation: Yes
Ages: 21-85
Non-Oncology
Duke University Hospital
Cancer Immunotherapy

We are doing this study to find out if an experimental drug called PT217 (the study drug) is a safe and effective option for people who have neuroendocrine carcinomas. We want to see how this drug works when it is given on its own and in combination with standard chemotherapy and/or immunotherapy drugs.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Blood Disorders

We are doing this study to find out if a new type of assessment works well for middle-aged and older adults with sickle cell disease (SCD). We want to see if this assessment is useful in detecting changes in health. We hope the assessment can provide useful information to help improve the quality of life for adults with sickle cell disease.

Compensation: Yes
Ages: 40-110
Non-Oncology
Duke University Hospital
Breast Cancer

We are doing this study to find out if an experimental drug called lasofoxifene (the study drug) is a safe and effective option for breast cancer. We want to see if the study drug combined with another drug called abemaciclib has better results than treatment with abemaciclib plus fulvestrant.

Compensation: Yes
Ages: 18-89
Oncology
Duke University Hospital, Duke Raleigh Hospital
Pregnancy Concerns

We are doing this study to learn more about how different factors in pregnancy lead to healthy babies. Specifically, whether factors related to father's health affect the placenta and baby, what part of placental and fetal genes are related to placenta health and baby growth, and to find out the best time to deliver when the mother has gestational diabetes.

Compensation: Yes
Ages: 18-110
Non-Oncology
Duke University Hospital, Duke Regional Hospital, Other
Research for Children and Teenagers

We are doing this study to find out if an experimental drug called Zorevunersen (the study drug) can effectively reduce the frequency of major motor seizures for children who have Dravet syndrome.

Compensation: No
Ages: 2-17
Non-Oncology
Duke University Hospital, Other

We are doing this study to learn more about how environmental contaminants (e.g., "forever chemicals") can affect people's likelihood of developing liver disease.

Compensation: Yes
Ages: 40-75
Duke University Hospital