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We are doing this study to find out if an experimental drug called PT217 (the study drug) is a safe and effective option for people who have neuroendocrine carcinomas. We want to see how this drug works when it is given on its own and in combination with standard chemotherapy and/or immunotherapy drugs.

We are doing this study to find out if a new type of assessment works well for middle-aged and older adults with sickle cell disease (SCD). We want to see if this assessment is useful in detecting changes in health. We hope the assessment can provide useful information to help improve the quality of life for adults with sickle cell disease.

We are doing this study to find out if an experimental drug called lasofoxifene (the study drug) is a safe and effective option for breast cancer. We want to see if the study drug combined with another drug called abemaciclib has better results than treatment with abemaciclib plus fulvestrant.

We are doing this study to learn more about how different factors in pregnancy lead to healthy babies. Specifically, whether factors related to father's health affect the placenta and baby, what part of placental and fetal genes are related to placenta health and baby growth, and to find out the best time to deliver when the mother has gestational diabetes.

If you can join, you will be placed in Part A or Part B based on when you start. In Part A, you will get one of three study medicines: SPY001, SPY002, or SPY003. In Part B, you will get one of these medicines, a mix of two medicines, or a placebo, which does nothing. The study will last about 97 weeks, and you will have around 20 visits or phone calls. During these, doctors will do tests like blood draws, endoscopy with biopsy, heart checks, and x-rays.

We are doing this study to find out if the Nectero EAST System® (the study procedure) is a safe and effective option for treating abdominal aortic aneurysms that are small to medium in size.

If you participate, you will be asked to provide a blood draw of about 5.4 mL, or 1/3 tablespoon, of blood. If you are one of the first 20 subjects, you may have the chance to participate in one additional blood draw.

This study has three parts, called Sub-Studies. In Sub-Study 1, people receive a medicine called duvakitug. In Sub-Study 2, people are placed by chance into one of three groups and may get duvakitug, a placebo with no medicine, or both depending on the group. In Sub-Study 3, people are placed by chance into one of two groups to get different doses of duvakitug. The whole study lasts about thirty-five weeks and includes fifteen clinic visits. During these visits, people will have tests such as heart checks, blood tests, endoscopy, biopsies, and questionnaires. Depending on when a person joins, they will be placed in Sub-Study 1 or Sub-Study 2. In both of these, they will take the study drug every two weeks for twelve weeks. After finishing one of these parts, they may be asked to join Sub-Study 3 for another twelve weeks of treatment, or they may be asked to join a different study called STARSCAPE 2.