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472 clinical trials found.
Brain, Spinal Cord and Nerves

We are doing this study to help develop a tool that doctors can use to figure out who might be at risk for developing muscle spasticity after a stroke. Spasticity is abnormal muscle stiffening that can lower people's strength and ability to move well. We hope this tool can help doctors catch this problem early and start treatment sooner to make therapy more effective.

Compensation: Yes
Ages: 21-110
Non-Oncology
Duke University Hospital
Blood Disorders

We are doing this study to get a better understanding of what predicts severe pain in teenagers and young adults living with sickle cell disease.

Compensation: No
Non-Oncology
Thoracic Cancer

We are doing this study to find the most effective, safe dose of an experimental drug called ONC-392 (the study drug). We want to know how well it works compared to the standard chemotherapy drug, docetaxel, for treating NSCLC.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital, Duke Raleigh Hospital
Remote

We are doing this study to find out if taking the study drug (Atorvastatin) can help older adults live longer and healthier by preventing dementia, disability, or heart disease. *The study drug is a statin, which is usually used to help lower cholesterol levels.

Compensation: Yes
Ages: 75-110
Non-Oncology
Pickett Road Research, Kannapolis, Other

In this study, people will first have a screening visit to make sure they can join and to check their pain and smoking habits. Next, they will have a training session to learn about the fake MRI scanner and how pain testing works. After that, they will have two brain scan sessions. For one scan, they will not smoke for 24 hours. For the other scan, they will smoke like normal. During each scan, they will feel heat pain and rate how it feels. Before and after each scan, they will answer questions about cravings, withdrawal, mood, and pain. There will be at least 2 days between the two scan sessions.

Compensation: Yes
Ages: 21-65
Duke University Hospital
Hematologic Malignancies and Cellular Therapy

We are doing this study to test a device that tracks urine and stool output from people when they are in the hospital. This study is important because if the device works, it can improve patients' comfort while they are recovering from a stem cell transplant.

Compensation: No
Oncology
Lungs and Breathing

We are doing this to develop a test that could help predict a common complication after lung transplant called primary graft dysfunction (PGD). Examining the medical records of transplant recipients and their donors will help us find the data we need to create this prediction tool.

Compensation: No
Non-Oncology
Research for Children and Teenagers

We are doing this study to find out how common it is for exocrine pancreatic insufficiency (EPI) to be present in children who have or are suspected to have celiac disease. We also want to compare different methods of testing for EPI in this study.

Compensation: No
Ages: 0-17
Non-Oncology
Duke University Hospital, Other