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442 clinical trials found.
Gynecologic Cancer

We are doing this study to compare 2 different procedures for treating cervical cancer and find out which approach has the best outcomes for patients. The two procedures that we will compare are open surgery with a single large incision (laparotomy) and robotic assisted laparoscopy (small incision surgery). We do not know which option is preferable in most cases, and we hope this study can help us find out which procedure is the better choice for patients.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital, Duke Raleigh Hospital
Lungs and Breathing

We are doing this study to find out if an investigational drug called belumosudil (the study drug) is an option for the treatment of chronic lung allograft dysfunction (CLAD). The study drug is taken by mouth.

Compensation: Yes
Ages: 18-110
Non-Oncology
Duke University Hospital
Research for Healthy Adults

We are doing this study to understand how sex hormones (chemicals that tell cells and body parts to do certain things), such as estrogens and androgens, impact skin diseases like hidradenitis suppurativa (HS). To better understand this, we are enrolling both people who have diagnosed skin diseases and healthy volunteers who have no skin issues.

Compensation: Yes
Ages: 18-46
Non-Oncology
Duke University Hospital
Heart and Circulation

We are doing this study to determine the effect of single vs multiple arterial revascularization (this is the restoration of blood flow to an organ) for female patients undergoing coronary artery bypass surgery (CABG).

Compensation: No
Ages: 18-110
Non-Oncology
Duke University Hospital, Duke Regional Hospital, Duke Raleigh Hospital
Hematologic Malignancies and Cellular Therapy

We are doing this study to find out if an investigational drug called OBI-3424 is a safe and effective option for patients with leukemia or lymphoma.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Gastrointestinal Cancer

We are doing this study to find out if either of 2 different, experimental drug regimens (ramucirumab plus paclitaxel or FOLFIRI) is an option for treating small bowel cancer that has not responded to therapy.

Compensation: No
Oncology
Hematologic Malignancies and Cellular Therapy

We are doing this study to compare the early treatment (before you have cancer symptoms) of Venetoclax and Obitnutuzumab (V-O) to the usual treatment of V-O after you have cancer symptoms. This study will help doctors figure out if early treatment is better, the same, or worse than the usual approach of waiting until the patient has cancer symptoms before starting treatment.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital