Purpose of this Study
We are doing this study to learn more about how different factors in pregnancy lead to healthy babies. Specifically, whether factors related to father's health affect the placenta and baby, what part of placental and fetal genes are related to placenta health and baby growth, and to find out the best time to deliver when the mother has gestational diabetes.
Who Can Participate?
Eligibility
Adults ages 18+ who:<ul>
<li>Are pregnant with one baby</li>
<li>Plan to deliver at Duke University Hospital or Duke Regional Hospital</li></ul>
The father of the baby can participate if mom enrolls.
For more information, contact the study team at <a href= "mailto: caroline.nagle@duke.edu">caroline.nagle@duke.edu.</a>
<li>Are pregnant with one baby</li>
<li>Plan to deliver at Duke University Hospital or Duke Regional Hospital</li></ul>
The father of the baby can participate if mom enrolls.
For more information, contact the study team at <a href= "mailto: caroline.nagle@duke.edu">caroline.nagle@duke.edu.</a>
Age Range
18-110
Sex/Genders
Male (cisgender)
Female (cisgender)
Non-binary or gender fluid
Transgender male
Transgender female
Looking for Healthy Participants
No
What is Involved?
If you choose to join this study, it will involve:<ul>
<li>An enrollment visit before 24 weeks gestation - we will take your body measurements, record your vital signs, collect samples (blood, urine, saliva), measure your arterial stiffness with a cuff on your thigh, and give you some surveys to fill out.</li>
<li>A 3rd trimester visit - we will take an ultrasound of your baby, take your body measurements, record your vital signs, and collect a blood sample.</li>
<li>Delivery visit - we will collect cord blood and placenta samples, and your baby will have a newborn exam.</li></ul>
<li>An enrollment visit before 24 weeks gestation - we will take your body measurements, record your vital signs, collect samples (blood, urine, saliva), measure your arterial stiffness with a cuff on your thigh, and give you some surveys to fill out.</li>
<li>A 3rd trimester visit - we will take an ultrasound of your baby, take your body measurements, record your vital signs, and collect a blood sample.</li>
<li>Delivery visit - we will collect cord blood and placenta samples, and your baby will have a newborn exam.</li></ul>
Locations
Duke University Hospital
Duke Regional Hospital
Other
Visit Timing
Weekdays
Compensation
Yes
Spanish Materials Available
Yes
Study Details
Full Title
Study of Pregnancy And Neonatal health (SPAN), pregnancy cohort investigating paternal contributions, placental/fetal genetics, and timing of delivery on neonatal health
Principal Investigator
Brenna
Hughes
Protocol Number
PRO00104812
NCT ID
NCT05515744
Phase
N/A
Enrollment Status
Open to Enrollment