Clinical Trials Directory

402 clinical trials found.
Breast Cancer

We are doing this study to better understand how breast cancer treatment can affect the heart. In particular, we want to know if treatment with near complete estrogen deprivation (NCED) therapy has an impact on heart function.

Compensation: Yes
Ages: 18-55
Oncology
Duke University Hospital, Duke Raleigh Hospital, Other
Cancer Immunotherapy

We are doing this study to find out if an experimental drug called CTX131 (the study drug) is a safe and effective treatment for different forms of cancer with solid tumors. The study drug is made from white blood cells or T cells from healthy donors.

Compensation: No
Oncology
Gynecologic Cancer

We are doing this study to find out if using ice with or without compression during chemotherapy can prevent neuropathy for patients being treated for gynecologic cancer.

Compensation: No
Ages: 19-110
Oncology
Duke University Hospital, Duke Raleigh Hospital
Surgery and Rehabilitation

We are doing this study to find out if an experimental product called cryopreserved platelets (CPP) can help control the bleeding that happens during and after cardiopulmonary bypass surgery. We want to see how well this product works in comparison to the standard therapy that is used to control bleeding during surgery, which is liquid stored platelets (LSP).

Compensation: No
Ages: 18-110
Non-Oncology
Duke University Hospital

We are doing this study to collect cerebrospinal fluid (CSF) samples from people with cancer that has spread to the leptomeninges (the inner membranes that cover the brain and spinal cord). These CSF samples will be used in laboratory research projects to identify substances called biomarkers. Biomarker testing is a way to look for genes, proteins, and other substances (tumor markers) that can provide information about cancer. Information from these CSF samples may help us learn about new methods to treat metastatic disease to the leptomeninges.

Compensation: No
Ages: 18-110
Duke University Hospital
Genitourinary Cancer

We are doing this study learn more about circulating immune cells and circulating tumor cells (CTCs) in patients with metastatic renal cell carcinoma or metastatic urothelial carcinoma. We are also looking at the bacteria in your gut and urinary tract to learn about how these bacteria affect how your cancer responds to immunotherapy.

Compensation: No
Oncology
Lungs and Breathing

We are doing this study to find out if an investigational drug called tocilizumab (the study drug) will lead to better outcomes after lung transplantation when it is combined with standard anti-rejection medicines.

Compensation: No
Ages: 18-110
Non-Oncology
Duke University Hospital
Heart and Circulation

We are doing this research to learn more about whether taking a blood thinner, along with medications that prevent blood clots, improve outcomes in patients who develop atrial fibrillation (irregular heartbeat) after coronary artery bypass grafting surgery.

Compensation: No
Ages: 18-110
Non-Oncology
Duke University Hospital, Duke Regional Hospital