Clinical Trials Directory

469 clinical trials found.
Breast Cancer

We are doing this study to find out if an experimental drug called lasofoxifene (the study drug) is a safe and effective option for breast cancer. We want to see if the study drug combined with another drug called abemaciclib has better results than treatment with abemaciclib plus fulvestrant.

Compensation: Yes
Ages: 18-89
Oncology
Duke University Hospital, Duke Raleigh Hospital
Pregnancy Concerns

We are doing this study to learn more about how different factors in pregnancy lead to healthy babies. Specifically, whether factors related to father's health affect the placenta and baby, what part of placental and fetal genes are related to placenta health and baby growth, and to find out the best time to deliver when the mother has gestational diabetes.

Compensation: Yes
Ages: 18-110
Non-Oncology
Duke University Hospital, Duke Regional Hospital, Other

If you participate, you will be asked to provide a blood draw of about 5.4 mL, or 1/3 tablespoon, of blood. If you are one of the first 20 subjects, you may have the chance to participate in one additional blood draw.

Compensation: Yes
Ages: 22-65
Duke University Hospital
Research for Children and Teenagers

We are doing this study to find out if an experimental drug called Zorevunersen (the study drug) can effectively reduce the frequency of major motor seizures for children who have Dravet syndrome.

Compensation: No
Ages: 2-17
Non-Oncology
Duke University Hospital, Other

We are doing this study to learn more about how environmental contaminants (e.g., "forever chemicals") can affect people's likelihood of developing liver disease.

Compensation: Yes
Ages: 40-75
Duke University Hospital
Infectious Diseases

This study doesn't give any treatment. Instead, doctors will collect samples like blood, pee, spit, and a nose swab two times while you're in the hospital. Later, someone from the study will call you after 60 days to ask how you're feeling.

Compensation: Yes
Ages: 18-110
Non-Oncology
Brain and Spine Metastasis

We are doing this study to see if the study drug, PT886, with or without chemotherapy and/or pembrolizumab, is a safe and effective option for gastric and pancreatic cancer. We are also trying to find the best dose of the study drug to use.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Brain and Spine Metastasis

We are doing this study to see if the study drug, QTX3034, either with or without cetuximab, is safe and effective for treating KRAS G12D mutated cancer. We are also trying to find the best dose of QTX3034 to use.

Compensation: No
Oncology