Clinical Trials Directory

514 clinical trials found.
Primary Brain and Spinal Cord Tumors

We are doing this study to find out how safe and effective it is to give people with recurrent glioblastoma two infusions of an experimental drug called lerapolturev (the study drug) in residual disease (within tumor margins) after surgery. After these two doses, we will give further doses of the study drug as injections in the subcutaneous area (under the skin) around the lymph nodes of the head and neck. We also want to know how well the study drug works compared to lomustine, which is a standard form of chemotherapy (drug used to kill cancer cells).

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Thoracic Cancer

We are doing this study to find out if a personalized exercise program designed for lung cancer patients can help with recovery from lung surgery. The study's exercise program is delivered over the phone.

Compensation: Yes
Ages: 65-110
Oncology
Duke University Hospital
Breast Cancer

We created this registry for people with rare breast tumors to help us learn more about them and how to better treat people in the future.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Kidneys, Bladder and Urinary System

We are doing this study to find out if an experimental drug called ravulizumab (the study drug) is a safe and effective option to prevent or reduce the severity of delayed graft function after people with end-stage kidney disease (ESKD) get a kidney transplant.

Compensation: Yes
Ages: 18-110
Non-Oncology
Duke University Hospital
Brain, Spinal Cord and Nerves

The purpose of this study is to see how a treatment called TMS can help people move their arms better. TMS stands for transcranial magnetic stimulation. It uses magnets to help the brain work in a different way. TMS is already approved to help people with depression, and doctors have also looked at how it helps people after a stroke. But scientists still need to learn the best way to use it to help people recover.

Compensation: Yes
Ages: 21-110
Non-Oncology
Duke University Hospital
Sarcoma

If you join this study, you will have the surgery your doctor planned. You can choose to use the regular tool or be randomly picked to use either the regular tool or a new one. Blood will be taken three times (before, during, and after surgery). Doctors will also check your regular cancer visits for one year. The study does not add extra visits or tests.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Breast Cancer

This study looks at different treatments for early breast cancer (DCIS). It has four parts: - Screening: Doctors do tests to see if you can join. - Treatment: You’re randomly placed in a group to get either standard medicine or a new treatment. - Surgery Check: After 3 months, doctors decide if surgery is needed. - Follow-Up: You’ll get check-ups for up to 5 years, and yearly follow-ups for 10 years. Treatments may include pills, hormone therapy, or small pellets under the skin. You’ll also have tests like MRIs, mammograms, and blood samples.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital, Duke Raleigh Hospital