Clinical Trials Directory

We are doing this study to find out if an experimental study drug called RP1 (the study drug) is a safe and effective option for people who have advanced melanoma. We want to know how the study drug works when it is combined with a cancer drug called nivolumab in comparison to several other standard treatments for advanced melanoma (nivolumab + relatlimab OR nivolumab alone OR pembrolizumab alone).

We are doing this study to find out if an experimental drug called RP2 (the study drug) is a safe and effective option for people who have uveal melanoma (melanoma in the eye). We want to know how well the study drug works when it is combined with a drug called nivolumab, and we will compare its outcomes to treatment with the drug combination of nivolumab + ipilimumab.

We are doing this study to find out if a drug called rosuvastatin (an FDA-approved medication for lowering cholesterol) can help reduce symptoms and extend the life expectancy of people with liver cirrhosis. Although rosuvastatin is an approved and commonly prescribed drug, it is not approved for the treatment of cirrhosis.

During the hospital stay, the study team will collect small blood samples up to three times. The team will also gather information about your health from your medical records.

The RESTORATION study is exploring new ways to help people with depression after a stroke. Instead of using medicine, the study is testing whether regular aerobic exercise and a brain treatment called transcranial magnetic stimulation, or TMS, might work better when used together. The goal is to find out if this combination can help people feel better and recover more fully.

If you join this study, you will be placed into one of two groups by chance. One group will get pelvic floor physical therapy, which helps with bladder control and sexual function. The other group will get the same therapy plus sex therapy, which includes up to ten video sessions over six months with a trained therapist. These sessions will be audio recorded to make sure the program is being done the right way. Everyone in the study will receive a vacuum erection device and learn how to use it safely. You will fill out surveys about your health and sexual function when you start the study and again at 3, 6, 9, 12, 18, and 24 months. These surveys will ask about sexual function, urinary symptoms, physical health, activity, and mood. You will also take part in short recorded interviews at 6 and 12 months to talk about your experience.