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We are doing this study to learn more about the symptoms of menopause in women with sickle cell disease (SCD). We want to learn more about how hydroxyurea, pain, and other SCD-related complications can affect their menopause experience. We hope this study can help us more quickly and easily find out when women with SCD might be experiencing health complications related to menopause.

We are doing this study to find the most effective, safe dose of an experimental drug called bomedemstat (the study drug) for people with essential thrombocythemia who are unable to take hydroxyurea or do not get a benefit from it.

We are doing this study to find the most effective, safe dose of an experimental drug called petosemtamab (the study drug). We also want to know how well it works compared to the standard treatments used for metastatic/recurrent head and neck squamous cell carcinoma (HNSCC).

We are doing this study to identify new signs and symptoms of inflammatory bowel disease (IBD) in children and young adults. We want to improve at predicting the future course of IBD so that we can treat it better and faster. We also hope this study will help us learn how IBD develops so that we can make new treatments for IBD.

This study is testing a new medicine to help people with a certain illness. If you join, you'll be randomly picked (like flipping a coin) to get either the real medicine or a fake one (called a placebo). Everyone will also get another medicine called enzalutamide. - You'll take pills every day - some with food, some without. - Doctors will check your health often with things like blood tests, heart checks, and pictures of your body. - You'll visit the clinic every 4 weeks for about a year, then less often after that. - Even if your illness gets worse, you might still keep taking the medicine if it's helping you. - This study is not the usual way doctors treat this illness, but it might help in the future.

We are doing this study to find out if nighttime dosing of a sedative called dexmedetomidine (the study drug) can reduce the occurrence of delirium (a state of mental confusion) in older adults who have heart surgery.

This study wants to see if a medicine called minoxidil can help people heal better after breast reconstruction surgery. Minoxidil is already approved by the FDA and may work by helping more blood flow to the skin. Everyone in the study will get two solutions before surgery. One solution has the medicine and the other does not. One will be put on one breast and the other on the other breast. Neither the patient nor the doctor will know which is which. The solutions will be used every day for two weeks before surgery. After surgery, the study team will check how well the healing went to see if the medicine made a difference.

We are doing this study to learn more about how well a study intervention works to reduce distress caused by misophonia. This intervention combines neurostimulation and skills-based training that is designed to help people think differently.