Purpose of this Study
We are doing this study to find out if giving patients a drug called atezolizumab before and after surgery for recurrent glioblastoma can improve how their cancer responds.
Who Can Participate?
Eligibility
Adults ages 18+ who:
- Are diagnosed with glioblastoma (isocitrate dehydrogenase wildtype)
- Have a recurrence after treatment with radiation and temozolomide
- Plan to have surgery
What is Involved?
Description
If you join the study, you will:
- Have a physical exam and other tests
- Have magnetic resonance imaging (MRI) scans of the brain
- Have blood draws
- Get atezolizumab before surgery
- Get atezolizumab after surgery
Study Details
Full Title
A Multicenter Trial to Identify Optimal Atezolizumab Biomarkers in the Setting of Recurrent Glioblastoma. The MOAB Trial
Principal Investigator
Mustafa
Khasraw
Protocol Number
PRO00113395
NCT ID
NCT06069726
Phase
II
Enrollment Status
Open to Enrollment