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604 clinical trials found.
Gastrointestinal Cancer

We are doing this study to help create a national biobank of samples and data about patients who experience side effects when they take immunotherapy drugs for their cancer. We want to find out why some people experience side effects and why others do not. We also want to learn more about how to diagnose and treat these side effects more effectively.

Compensation: No
Ages: 18-110
Oncology
Duke Raleigh Hospital
Cancer Prevention and Screening

We are doing this study to test a new strategy to help people quit smoking. We want to know if the study approach is better than the usual approach. The usual approach is to encourage patients to quit smoking using cessation support manuals and either medication or nicotine replacement products. We want to know if the study approach works better for cancer survivors who live in rural areas.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital, Other
Gastrointestinal Cancer

In this study, you will be placed into one of two treatment groups. One group will receive two medicines called telisotuzumab adizutecan and bevacizumab, given through a vein every three weeks. The other group will receive bevacizumab through a vein every two weeks and take a medicine called LONSURF by mouth on a repeating schedule. You will keep taking the study medicines as long as they are helping and side effects are manageable. Treatment is expected to last about one year. During treatment, you will have regular clinic visits and medical tests to check your health. After stopping the study medicines, you will have follow up visits at two weeks, one month, and about three months, and then the study team will check on you every three months to see how you are doing.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital, Duke Raleigh Hospital
Gastrointestinal Cancer

People in this study will be in one of two groups. One group will get a medicine called ABBV-400 through an IV every 21 days. The other group will not get medicine but will have blood tests for cancer DNA and imaging scans to check for cancer.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital, Duke Raleigh Hospital
Gastrointestinal Cancer

What happens in this study? - You'll get the study medicine through an IV every 3 weeks - Depending on your group, you might also get: - Budigalimab (a new medicine being tested) - Or a standard cancer medicine - You'll give blood and urine samples - You'll have regular CT or MRI scans to check your health

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Surgery and Rehabilitation

We are doing this study to understand if the abdominal wall transplant can repair defects in the abdominal wall.

Compensation: No
Ages: 18-65
Non-Oncology
Duke University Hospital
Radiation Oncology

We are doing this study to collect information about people with oligometastasis for future use.

Compensation: No
Ages: 18-110
Oncology
Remote/online
Breast Cancer

This study lasts about twelve months and includes around twelve to eighteen visits, most of which are regular visits you would have even if you were not in a study. The study is testing a device called the Melodi Matrix. It is a special mesh that has medicine to fight bacteria. The mesh is placed around tissue expanders before they are put into the body. After about nine weeks, the mesh dissolves and is absorbed by the body.

Compensation: Yes
Ages: 22-110
Oncology
Duke University Hospital, Other