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We are doing this study to see if the study drugs ABBV-400 and budigalimab, in combination with chemotherapy, are a safe and effective option for treating gastroesophageal cancer. We are also trying to find the best dose of ABBV-400 to use.

People in this study will be in one of two groups. One group will get a medicine called ABBV-400 through an IV every 21 days. The other group will not get medicine but will have blood tests for cancer DNA and imaging scans to check for cancer.

What happens in this study? - You'll get the study medicine through an IV every 3 weeks - Depending on your group, you might also get: - Budigalimab (a new medicine being tested) - Or a standard cancer medicine - You'll give blood and urine samples - You'll have regular CT or MRI scans to check your health

We are doing this study to understand if the abdominal wall transplant can repair defects in the abdominal wall.

We are doing this study to collect information about people with oligometastasis for future use.

The COMET Study includes up to 4 visits to the study center. Each visit lasts about 2 to 3 hours. During the visits, children will wear special equipment for a brain test called an EEG and do fun, play-based activities. Parents or caregivers may be asked to answer questions or do interviews at home. Families will get $50 for each visit.

We are doing this study to compare measures of brain function after surgical circulatory arrest ( when the surgeon stops the heart-lung machine to work on your heart) in antegrade perfusion versus retrograde perfusion. Antegrade and retrograde perfusion are 2 different ways to supply blood to the brain during this type of surgery. In antegrade perfusion, the surgeon accesses one of two arteries that branch off from the aorta (the artery that delivers blood to the rest of the body) to provide blood to the brain. In retrograde perfusion, the surgeon accesses the superior vena cava (large vein bringing blood back to the heart) to supply blood to the brain. Both methods are commonly used, but we want to find out if one method works better for most people than the other.

People in the study will have visits every 6 months for up to 5 years. At these visits, doctors will take blood and urine samples. At some visits, they will do a heart test called an echocardiogram and ask questions about how the person feels and their quality of life. At each visit, participants will get a medicine called Acoramidis to take two times every day.