Purpose of this Study
We are doing this study to learn more about Alzheimer's disease and other illnesses of aging (e.g., dementia, mild cognitive impairment [MCI], or other cognition disorders).
Who Can Participate?
Eligibility
Adults ages 45-80 who:
- Are be able to read at a 6th grade level
- Are willing to have an MRI scan and a lumbar puncture or PET scan
- Have a study partner
Age Range
25-80
Sex/Genders
Male (cisgender)
Female (cisgender)
Non-binary or gender fluid
Transgender male
Transgender female
Looking for Healthy Participants
Yes
What is Involved?
Description
This study will ask that you have a study partner. This is usually a family member that can answer questions about your day-to-day activities.
If you choose to join this study, you will:
- Complete 3 study visits in 60 days and then yearly visits after that
- Do brain and thinking tests
- Have physical exams
- Do memory tests
- Complete medical and family history surveys
- Get a brain MRI (image)
- Have a lumbar puncture (spinal tap) or PET Scan
- Do memory testing
- Have a blood test
Locations
Duke University Hospital
Visit Timing
Weekdays
Compensation
Yes
Spanish Materials Available
No
Study Details
Full Title
Duke Alzheimer's Disease Center Clinical Cohort (Duke as Single IRB of Record)
Study Website
Principal Investigator
Heather
Whitson
Protocol Number
PRO00103958
NCT ID
NCT06703541
Phase
N/A
Enrollment Status
Open to Enrollment