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544 clinical trials found.
Brain, Spinal Cord and Nerves

We created the Registry for Brain Health to help you improve your brain health and get involved in research studies. The number of people in North Carolina affected by memory disorders, such as Alzheimer's disease and other forms of dementia, is going up. To change that, we must work together, stay informed, and get involved. We are enrolling both people who have memory problems and people who are healthy and do not have memory problems.

Compensation: No
Ages: 18-110
Non-Oncology
Other
Skin Cancer - Melanoma

We are doing this study to find out if an investigational called Daromun (the study drug) is a safe and effective treatment for melanoma. We want to know if treating people with the drug before surgery to remove tumors can lower the chance of cancer recurrence.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Mental Health, Behavior, and Substance Abuse

We are doing this study to find out if combining psychological skills and a procedure called neurostimulation during one clinic session can help reduce negative emotions and problems with dealing with emotions in both a laboratory setting and in a person's everyday life.

Compensation: Yes
Ages: 18-55
Non-Oncology
Duke University Hospital
Brain, Spinal Cord and Nerves

We are doing this study to collect information about the speeds of eye and head movements in healthy children and young adults. This information will help us establish normal values related to these movement speeds and patterns. If we have a measure of what is normal, this will help us determine the severity of symptoms or injury for people who are treated for concussions.

Compensation: Yes
Ages: 12-25
Non-Oncology
Duke University Hospital, Duke Regional Hospital, Duke Raleigh Hospital, Pickett Road Research, Other
Blood Disorders

In this study, everyone will receive a medicine called ianalumab that is given through a vein. People will get this treatment once every four weeks for four doses. During this time, they will come to the clinic each week to have blood tests to check their platelet levels. They will also take another medicine chosen by the study doctor to help increase platelets. After the last dose of the study medicine, participants will continue to have weekly blood checks for 16 weeks. After that, they will have blood checks once a month for one year. The goal is to closely watch how their blood counts change over time and see how well the treatment works.

Compensation: Yes
Ages: 18-110
Non-Oncology
Duke University Hospital
Breast Cancer

We are doing this study to compare two commonly used treatment choices for early-stage breast cancer in premenopausal women. We want to know if either option is a better choice than the other.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital, Duke Raleigh Hospital, Other
Radiation Oncology

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Gastrointestinal Cancer

We are doing this study to find out if a blood test for circulating tumor DNA (ctDNA) can provide information that might help doctors figure out the most appropriate therapy for patients with colon cancer after they have surgery.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital, Duke Raleigh Hospital