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435 clinical trials found.
Genitourinary Cancer

We are doing this study to find the most effective, safe dose of an experimental drug called pocenbrodib (the study drug). We want to see how it works when it is given by itself and also when it is given with other drugs already approved for the treatment in people with metastatic castration-resistant prostate cancer (mCRPC).

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital

We are doing this study to test a program that is being developed by nurses to help patients with HER2+ metastatic breast cancer manage their treatment with three drugs typically used for this diagnosis: tucatinib, trastuzumab, and capecitabine. The program's goal is to help patients manage symptoms and provide resources to improve their quality of life.

Compensation: Yes
Ages: 18-110
Remote/online
Inpatient Studies

If you choose to join this study, you or your child, will:

  • Allow us access to your medical record for up to 5 years
  • Answer questions about your health history and current symptoms
  • Have a nasal swab
  • Give a stool sample
  • Complete 3 follow-up phone calls
  • Have blood drawn (only if in the hospital or l)

Compensation: No
Non-Oncology
Gastrointestinal Cancer

We are doing this study to find out if pelvic floor physical therapy can improve sexual function for women who have undergone pelvic radiation.

Compensation: No
Ages: 19-110
Oncology
Remote/online
Radiation Oncology

We are doing this study to understand whether people who receive a lower radiation dose after an interim (the second scan) PET-CT identifies an early treatment response have a similar outcome to those receiving a standard radiation dose. The results of the interim PET-CT scan will be used to guide your radiation dose plan. Depending on the PET-CT results, you will either receive a reduced radiation dose or the standard radiation dose for your cancer.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital, Duke Raleigh Hospital
Phase I

We are doing this study to find the most effective, safe dose of an experimental drug called PF-0793440 (the study drug). We want to know how well it works on its own and in combination with other drugs for the treatment of different cancers in people who have KRAS mutation(s).

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Hematologic Malignancies and Cellular Therapy

We are doing this study to find out if an experimental drug called navtemadlin (the study drug) is a safe and effective option for people with myelofibrosis (MF). We want to know how well it works when it is combined with ruxolitinib for people who did not get the desired results from ruxolitinib on its own.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Hematologic Malignancies and Cellular Therapy

We are doing this study to find the most effective, safe dose of an experimental drug called CLN-049 (the study drug) for people with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS).

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital