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Before joining the study, adults will be screened, that lasts up to one month. During this time, they will sign a consent form, share their medical history and medicines, have exams, heart tests, lab tests, imaging, and sometimes a tumor biopsy and a test for a gene change called PIK3CA. If eligible and want to continue, they will join either Cohort 5 or Cohort 6. A computer may choose the group by chance, or they may be placed in a group directly if only one is open. Some groups may require extra biopsies. Each person will sign a new consent for the treatment they are given. In Cohort 5, people who are pre diabetic may take a medicine like empagliflozin or metformin XR to help manage blood sugar. They will also take inavolisib with fulvestrant, and sometimes palbociclib. The first treatment cycle is a longer, then the rest last 28 days each. In Cohort 6, each 28 day cycle includes inavolisib taken by mouth once a day, atirmociclib taken by mouth two times a day, and fulvestrant given as a shot.

We are doing this study to see how tucatinib, trastuzumab, and mFOLFOX6 work to treat cancer of your colon or rectum that is HER2-positive with mFOLFOX6 alone or combined with bevacizumab.

This study is being done to find out if atropine eyedrops (0.05% atropine, 99.95% inactive solution) and/or special eyeglass lenses are an effective strategy to slow down the progression of myopia for young children with nearsightedness.

We are doing this study to compare the usual treatment of azacitidine and venetoclax to the combination treatment of azacitidine, venetoclax and gilteritinib. We want to find out if adding gilteritinib to the usual treatment is beneficial for people with acute myeloid leukemia (AML).

We are doing this study to find out if 2 different experimental drug combinations can improve outcomes for people who are newly diagnosed with AML. We want to compare the outcomes from the standard treatment (cytarabine + daunorubicin) to the following experimental regimens:

• Venetoclax + cytarabine + daunorubicin
• Venetoclax + azacitidine

We are doing this study to compare different experimental drug regimens to the usual treatment (cytarabine and daunorubicin) for acute myeloid leukemia (AML). We want to find out which options have the best outcomes. The different drug combinations we will be testing against the usual treatment are:

• daunorubicin and cytarabine liposome
• cytarabine and daunorubicin with venetoclax
• azacitidine and venetoclax
• daunorubicin and cytarabine liposome with venetoclax

We are doing this study to see if blood and bone marrow samples can be tested in a timely manner that allows for the detection of certain markers that could guide cancer treatment.

We are using you or your child's medical information in this study to better understand the diagnosis, treatment, and complications of Spina Bifida.