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Everyone who joins this study will take a medicine called ribociclib by mouth once a day for 21 days, then have a 7-day break. This makes a 28-day cycle. They will also take hormone therapy (endocrine therapy) every day. This treatment will last for about 3 years (around 39 cycles). After finishing treatment or stopping early, patients will have a visit called End of Treatment and then a safety check 30 days later. After that, doctors will keep track of their health and survival for a long time—up to 4 years after the last person starts treatment.

We are doing this study to compare two commonly used treatment choices for early-stage breast cancer in premenopausal women. We want to know if either option is a better choice than the other.

We are doing this study to find out if a blood test for circulating tumor DNA (ctDNA) can provide information that might help doctors figure out the most appropriate therapy for patients with colon cancer after they have surgery.

We are doing this study to find out if adding radiation therapy has any positive benefit when it is added to the usual treatment regimen for this form of cancer.

Group 1: People in this group will get the usual chemotherapy and radiation treatment for this cancer. They will have radiation 5 days a week for 4 to 5 weeks. That means about 20 treatments in total. Group 2: People in this group will get the usual chemotherapy and a new way of giving radiation. This way uses fewer treatments with a higher dose. They will have radiation up to 2 days a week for up to 4 weeks. That means about 5 treatments in total.

We are doing this study to see if radiation and chemotherapy can be done instead of an extensive surgical removal of the groin lymph nodes for patients with vulvar cancer whose disease has spread to the sentinel node. We are doing this study because we want to find out if this approach is better or worse than the usual approach for vulvar cancer.