Clinical Trials Directory

402 clinical trials found.
Hematologic Malignancies and Cellular Therapy

We are doing this study to find the most effective, safe dose of an experimental drug called iadademstat (the study drug). We want to know if the study drug is beneficial for people with R/R AML that have the FLT3 mutation when it is given in combination with gilteritinib.

Compensation: No
Oncology
Breast Cancer

We are doing this study to find out if anti-HER2 treatment can be safely stopped in patients with metastatic HER2+ breast cancer who have had an exceptional response to treatment for at least 3 years.

Compensation: No
Oncology
Eyes and Vision

We are doing this study to find out if an ophthalmic insert called Dextenza can be used to control eye inflammation and pain in pediatric patients after routine retinal surgery or laser treatment.

Compensation: Yes
Ages: 3-17
Non-Oncology
Duke University Hospital
Heart and Circulation

We are doing this study to learn more about the effects of exercise and medication on symptoms of worry and stress in adults with heart disease. This study is important because symptoms of worry and stress are risk factors for worsening heart health.

Compensation: No
Non-Oncology
Heart and Circulation

We are doing this to compare the results of early surgical intervention to medical therapy. We want to know if there is a difference in outcomes for these treatment options. We also want to track the health and progress of people with a large ascending aortic aneurysm (a bulge in the aorta caused by weakening in the artery wall).

Compensation: No
Non-Oncology
Thoracic Cancer

We are doing this study to see how an experimental drug called evolocumab (study drug) works in your body and against your cancer when it is given in combination with approved immunotherapy drugs.

Compensation: No
Ages: 18-100
Oncology
Duke University Hospital, Duke Raleigh Hospital
Cancer Immunotherapy

We are doing this research study to learn about the safety and effectiveness of alirocumab (a cholesterol-lowering drug) when it is combined with cemiplimab (an immunotherapy drug) and preoperative chemotherapy in patients with stage 1B-3A non-small cell lung cancer (NSCLC) who will undergo surgery. This study is important because it might potentially improve outcomes for you and other future patients.

Compensation: No
Oncology
Infectious Diseases

We are doing this study to find out if an investigational drug called ensitrelvir (the study drug) is an effective option when it is given along with the current standard treatment for COVID-19.

Compensation: No
Ages: 18-100
Non-Oncology
Duke University Hospital, Duke Regional Hospital, Duke Raleigh Hospital, Pickett Road Research