Clinical Trials Directory
This study will last about 8 weeks, but the time can change based on your schedule. People in the study will smoke special cigarettes instead of their usual ones. These cigarettes will have either a normal amount of nicotine or a very low amount. Which type you get will be random, like flipping a coin. Participants will have several visits: a remote screening (2 hours), an in-person screening (1 hour), two sessions after not smoking for 24 hours (90 minutes each), and five weekly visits (60–90 minutes each). There is also an optional part with four visits over 12 weeks to help quit smoking.
Babies in this study will be followed while they are in the hospital, for up to 30 days or until they go home, whichever comes first. Babies who receive a short course of the antibiotic ampicillin will have a small blood sample taken about two days after the medicine is started to see how the drug is working in their body. Some babies may have extra blood samples taken if they are already having routine lab tests, but this is not required. The study team will also collect basic information about the baby, their medical care, and details about the blood samples to help researchers learn more.
We are doing this study to find out if non-opioid means of pain relief are adequate for children who need mechanical ventilation for the treatment of acute respiratory failure. We want to know if acetaminophen and/or ketorolac can help provide enough relief to lower the need for using opioids to treat pain. Opioid pain medications have side effects (e.g., withdrawal symptoms and delirium) that can potentially be lessened if the study drugs are shown to provide an acceptable benefit.
We are doing this study to find out what pain management options work best for most children who have surgery to remove their tonsils (tonsillectomy). We will compare the outcomes of using fentanyl (a short-acting opioid) versus using methadone (a long-acting opioid) to control pain during and after surgery. Both drugs are commonly used for this purpose, but we don't have enough data to know which is the best option to reduce pain.
We are doing this study to find out what strategy after surgery has the best outcomes for patients with triple-negative breast cancer who have a complete response to chemotherapy before their surgeries. We want to compare 27 weeks of treatment with pembrolizumab after surgery to 27 weeks of monitoring without drug treatment and find out if there is a difference in terms of risk of having the cancer come back.
In this study, people are placed by chance into one of three groups. Each group uses different materials during spine surgery to help the bones heal and grow together. Two groups will use a material called OsteoAdapt SP with different amounts of a growth factor inside a small device placed between the bones. The third group will use standard bone materials taken from the patient or donated bone products. The study compares these groups to see which option helps the bones heal best after surgery.
On the day of surgery, before the child is given anesthesia, the doctor will use a device called the Novoscope to look at the eardrum. The doctor will gently blow small puffs of air into the ear to check how the eardrum moves. This only takes about one or two minutes for each ear. During the surgery, before the ear tube is placed, the doctor will collect a small sample of fluid from the middle ear. This sample will not have the child’s name on it and will be sent to a lab for testing.
This study will happen during a child’s visit to the emergency room. There will be no extra visits after this. A doctor will first check the ears like normal and share their opinion. Then the doctor will use the Novoscope. The tip of the Novoscope will go into the outer ear, just like a regular ear check. The eardrum will get a soft puff of air, and the doctor will record an ultrasound reading. Collecting readings takes only 1 to 2 minutes for each ear. The whole study will take about 20 to 30 minutes. The study is very safe. The risks are no greater than a regular ear exam.