Clinical Trials Directory
In this study, people will visit the clinic about every twelve weeks for checkups, lab tests, and other health exams. At each visit, they will receive a shot under the skin. The shot will either contain the study medicine, called olpasiran, or a placebo, which is a shot with no medicine in it. Participants are placed into one of these two groups by chance, like flipping a coin, and neither the doctor nor the participant will know which one they are getting. The study will last for several years. During this time, the team will check blood tests, look at heart health, and watch for any side effects. The main goal is to learn if olpasiran can safely lower Lp(a) levels and help prevent serious heart problems in the future.
People in this study may get a donor heart that is kept safe using a special system called the OCS Heart System, or they may get a heart kept cold in the usual way. Which one they get depends on the heart they are matched with. After the transplant, the study will collect information from their medical records for six months.
In this study, you will be placed into one of two groups by chance. One group will have donated lungs preserved using a special system called the OCS Lung System with a new solution. The other group will have the lungs preserved using the usual cold storage method. You will be followed from the time you agree to join the study until thirty days later or until you leave the hospital, whichever is longer. The study does not require any extra tests or visits. The study team will collect information from your medical records based on the care, tests, and procedures you already receive.
We are doing this study to compare activity in the brains of female adults who have chronic pain and/or use opioids to the brain activity of healthy female adults who are pain-free. We hope this study can help us develop new and targeted treatments for adults with chronic pain and alternatives to opioid therapy.
This study will last about 8 weeks, but the time can change based on your schedule. People in the study will smoke special cigarettes instead of their usual ones. These cigarettes will have either a normal amount of nicotine or a very low amount. Which type you get will be random, like flipping a coin. Participants will have several visits: a remote screening (2 hours), an in-person screening (1 hour), two sessions after not smoking for 24 hours (90 minutes each), and five weekly visits (60–90 minutes each). There is also an optional part with four visits over 12 weeks to help quit smoking.
Babies in this study will be followed while they are in the hospital, for up to 30 days or until they go home, whichever comes first. Babies who receive a short course of the antibiotic ampicillin will have a small blood sample taken about two days after the medicine is started to see how the drug is working in their body. Some babies may have extra blood samples taken if they are already having routine lab tests, but this is not required. The study team will also collect basic information about the baby, their medical care, and details about the blood samples to help researchers learn more.
We are doing this study to find out if non-opioid means of pain relief are adequate for children who need mechanical ventilation for the treatment of acute respiratory failure. We want to know if acetaminophen and/or ketorolac can help provide enough relief to lower the need for using opioids to treat pain. Opioid pain medications have side effects (e.g., withdrawal symptoms and delirium) that can potentially be lessened if the study drugs are shown to provide an acceptable benefit.
We are doing this study to find out what pain management options work best for most children who have surgery to remove their tonsils (tonsillectomy). We will compare the outcomes of using fentanyl (a short-acting opioid) versus using methadone (a long-acting opioid) to control pain during and after surgery. Both drugs are commonly used for this purpose, but we don't have enough data to know which is the best option to reduce pain.