Clinical Trials Directory

473 clinical trials found.
Lungs and Breathing

We maintain this registry to have a database of people with any type of lung or breathing disorder who are interested in participating in research about their lung condition.

Compensation: No
Ages: 18-65
Non-Oncology
Duke University Hospital
Heart and Circulation

We are doing this study to collect information about the clinical performance of the PulseSelect® Pulsed Field Ablation (PFA) System. The PFA system was recently approved by the FDA as a treatment for both paroxysmal and persistent atrial fibrillation (AF). We want to learn more about how well it works for AF patients now that it is a widely available option. We will assess how well it improves symptoms for people who who have persistent AF that has lasted less than one year, or have experienced episodes of paroxysmal atrial fibrillation, or have persistent or paroxysmal atrial fibrillation that is not controlled by medication, or have symptoms from their persistent or paroxysmal atrial fibrillation.

Compensation: Yes
Ages: 18-110
Non-Oncology
Duke University Hospital, Duke Raleigh Hospital
Primary Brain and Spinal Cord Tumors

We are doing this study to find out how safe and effective an experimental drug called MVR-C5252 (the study drug) is for people with advanced brain cancer.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Research for Children and Teenagers

If you choose to join this study, we will ask you questions about:

  • Your life at home
  • Your life at school
  • Your medical needs
We will ask you to answer these questions each year during one of your regular clinic visits.

Compensation: No
Non-Oncology
Hematologic Malignancies and Cellular Therapy

We are doing this study to find the most effective, safe dose of an experimental drug called quizartinib (the study drug) for people with acute myeloid leukemia (AML) who do not have a FLT3-ITD mutation and who have not completed any treatment for their disease.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Hematologic Malignancies and Cellular Therapy

We are doing this study to find the most effective, safe dose of an experimental drug called linvoseltamab (the study drug) in people with newly diagnosed multiple myeloma.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Primary Brain and Spinal Cord Tumors

We are doing this study to find out how safe and effective it is to give people with recurrent glioblastoma two infusions of an experimental drug called lerapolturev (the study drug) in residual disease (within tumor margins) after surgery. After these two doses, we will give further doses of the study drug as injections in the subcutaneous area (under the skin) around the lymph nodes of the head and neck. We also want to know how well the study drug works compared to lomustine, which is a standard form of chemotherapy (drug used to kill cancer cells).

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Thoracic Cancer

We are doing this study to find out if a personalized exercise program designed for lung cancer patients can help with recovery from lung surgery. The study's exercise program is delivered over the phone.

Compensation: Yes
Ages: 65-110
Oncology
Duke University Hospital