Clinical Trials Directory

We are doing this study to find out if non-opioid means of pain relief are adequate for children who need mechanical ventilation for the treatment of acute respiratory failure. We want to know if acetaminophen and/or ketorolac can help provide enough relief to lower the need for using opioids to treat pain. Opioid pain medications have side effects (e.g., withdrawal symptoms and delirium) that can potentially be lessened if the study drugs are shown to provide an acceptable benefit.

We are doing this study to find out what pain management options work best for most children who have surgery to remove their tonsils (tonsillectomy). We will compare the outcomes of using fentanyl (a short-acting opioid) versus using methadone (a long-acting opioid) to control pain during and after surgery. Both drugs are commonly used for this purpose, but we don't have enough data to know which is the best option to reduce pain.

We are doing this study to find out what strategy after surgery has the best outcomes for patients with triple-negative breast cancer who have a complete response to chemotherapy before their surgeries. We want to compare 27 weeks of treatment with pembrolizumab after surgery to 27 weeks of monitoring without drug treatment and find out if there is a difference in terms of risk of having the cancer come back.

In this study, people are placed by chance into one of three groups. Each group uses different materials during spine surgery to help the bones heal and grow together. Two groups will use a material called OsteoAdapt SP with different amounts of a growth factor inside a small device placed between the bones. The third group will use standard bone materials taken from the patient or donated bone products. The study compares these groups to see which option helps the bones heal best after surgery.

On the day of surgery, before the child is given anesthesia, the doctor will use a device called the Novoscope to look at the eardrum. The doctor will gently blow small puffs of air into the ear to check how the eardrum moves. This only takes about one or two minutes for each ear. During the surgery, before the ear tube is placed, the doctor will collect a small sample of fluid from the middle ear. This sample will not have the child’s name on it and will be sent to a lab for testing.

This study will happen during a child’s visit to the emergency room. There will be no extra visits after this. A doctor will first check the ears like normal and share their opinion. Then the doctor will use the Novoscope. The tip of the Novoscope will go into the outer ear, just like a regular ear check. The eardrum will get a soft puff of air, and the doctor will record an ultrasound reading. Collecting readings takes only 1 to 2 minutes for each ear. The whole study will take about 20 to 30 minutes. The study is very safe. The risks are no greater than a regular ear exam.

We are doing this study to improve treatment options for people with opioid use disorder. We want to know if a certain brain signal can better predict how someone will respond to buprenorphine (Suboxone®), and we also want to find out if a non-invasive treatment called repetitive Transcranial Magnetic Stimulation (rTMS) can help people quit opioids more easily than just taking buprenorphine alone. rTMS involves placing a coil against the scalp, and delivers magnetic pulses that stimulate a specific part of the brain. For this study, we will focus on the part of the brain involved with self-control. This procedure is FDA-approved for depression and is commonly used in other addiction treatments (smoking cessation).

We are doing this study to learn more about why some people develop pain syndromes after a stroke. We want to find out if certain brain areas, like the ventral posterior lateral nucleus of the thalamus and its connections, are linked to this pain.