Clinical Trials Directory
In this study, people will be placed into one of two groups by chance. One group will have a procedure to remove the kidney stone within about 90 days of joining the study. The other group will be closely monitored without having the stone removed right away. Everyone in the study will be followed for two years. Participants will have regular clinic visits, at least once each year, and will complete surveys every three months about any symptoms they have. Researchers want to learn which approach is better for people who have kidney stones that are not causing pain or other problems.
We are doing this study to find out which type of surgery has the best outcomes for people who have shoulder dislocations with bone loss. There are 3 types of surgeries that doctors can perform to stabilize the shoulder of people who have this type of injury, but there is no evidence at this time that proves one is better than the others. We hope this study can help us figure out how to choose the best option for different patients. This is an observational study and participation will not affect the treatment option you choose to pursue.
In this study, people will visit the clinic about every twelve weeks for checkups, lab tests, and other health exams. At each visit, they will receive a shot under the skin. The shot will either contain the study medicine, called olpasiran, or a placebo, which is a shot with no medicine in it. Participants are placed into one of these two groups by chance, like flipping a coin, and neither the doctor nor the participant will know which one they are getting. The study will last for several years. During this time, the team will check blood tests, look at heart health, and watch for any side effects. The main goal is to learn if olpasiran can safely lower Lp(a) levels and help prevent serious heart problems in the future.
People in this study may get a donor heart that is kept safe using a special system called the OCS Heart System, or they may get a heart kept cold in the usual way. Which one they get depends on the heart they are matched with. After the transplant, the study will collect information from their medical records for six months.
In this study, you will be placed into one of two groups by chance. One group will have donated lungs preserved using a special system called the OCS Lung System with a new solution. The other group will have the lungs preserved using the usual cold storage method. You will be followed from the time you agree to join the study until thirty days later or until you leave the hospital, whichever is longer. The study does not require any extra tests or visits. The study team will collect information from your medical records based on the care, tests, and procedures you already receive.
Participants will attend 1 or 2 study visits that last up to 4.5 hours. During the visits, they will have MRI scans, play thinking and memory games, complete sensory tests, and provide blood samples. Researchers will use this information to learn more about brain and body function. You can sign up for us to contact you here: https://redcap.duke.edu/redcap/surveys/?s=RXCMMCPWNKWJELN4
This study will last about 8 weeks, but the time can change based on your schedule. People in the study will smoke special cigarettes instead of their usual ones. These cigarettes will have either a normal amount of nicotine or a very low amount. Which type you get will be random, like flipping a coin. Participants will have several visits: a remote screening (2 hours), an in-person screening (1 hour), two sessions after not smoking for 24 hours (90 minutes each), and five weekly visits (60–90 minutes each). There is also an optional part with four visits over 12 weeks to help quit smoking.