Clinical Trials Directory

We are doing this study to find out if adding radiation therapy has any positive benefit when it is added to the usual treatment regimen for this form of cancer.

Group 1: People in this group will get the usual chemotherapy and radiation treatment for this cancer. They will have radiation 5 days a week for 4 to 5 weeks. That means about 20 treatments in total. Group 2: People in this group will get the usual chemotherapy and a new way of giving radiation. This way uses fewer treatments with a higher dose. They will have radiation up to 2 days a week for up to 4 weeks. That means about 5 treatments in total.

We are doing this study to see if radiation and chemotherapy can be done instead of an extensive surgical removal of the groin lymph nodes for patients with vulvar cancer whose disease has spread to the sentinel node. We are doing this study because we want to find out if this approach is better or worse than the usual approach for vulvar cancer.

This study has three groups. In each group, people receive medicines used to treat this type of cancer through a vein every three weeks for several treatment cycles. In the first group, people receive common cancer medicines along with another medicine called pembrolizumab. After this part, they continue with pembrolizumab alone for a longer time, with treatments given every six weeks for up to about two years. In another group, people receive a study medicine called bevacizumab together with standard cancer treatments. These medicines are also given through a vein during regular treatment cycles. The study is designed to compare these different treatment plans to see which works best and is safest for patients.

To join this study, patients must have bladder cancer proven by a lab test. The cancer must be in stages called cT2 to T3 and must not have spread to the lymph nodes or other parts of the body. Before joining, patients need a surgery called TURBT to remove as much of the tumor as possible. Patients also need scans of the chest, belly, and pelvis using CT or MRI to make sure the cancer has not spread. If any lymph nodes look big, they must be tested to show there is no cancer. Patients cannot have cancer that has spread or certain types of bladder cancer. Patients must be 18 or older. They cannot have had radiation to the pelvis before. If they had other treatments, any side effects must be mostly gone.

We are doing this study to find out if stereotactic body radiation therapy (SBRT) might be beneficial for people with non-small cell lung cancer (NSCLC). We want to compare the outcomes between the standard treatment for NSCLC and the standard treatment with the addition of SBRT.

We are doing this study to find the most effective, safe dose of an experimental drug called NX-5948 (the study drug). We want to know how well this study drug works in people with B-cell lymphomas.