Clinical Trials Directory

444 clinical trials found.
Brain and Spine Metastasis

We are doing this study to find out if an experimental drug called RMC-6236 (the study drug) is a safe and effective option for people with metastatic pancreatic ductal adenocarcinoma (PDAC). We want to see how well the study drug works compared to the standard chemotherapy regimen for PDAC.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Digestive System

We are doing this study to learn more about the long-term effectiveness of an approved medicine that is prescribed for the treatment of EoE. We want to know how will dupilumab (Dupixent®) works over time when EoE patients and their doctors choose it as therapy. Dupilumab was approved by the FDA in May 2022 to treat EoE and was the first drug approved for this purpose.

Compensation: Yes
Ages: 18-110
Non-Oncology
Duke University Hospital
Digestive System

We are doing this study to find out if an experimental drug called dupilumab can help reduce inflammation in the stomach and small intestines for adults or children who are diagnosed with EoG.

Compensation: Yes
Ages: 12-110
Non-Oncology
Duke University Hospital
Heart and Circulation

We are doing this study to find out if an experimental device is a safe and effective method to repair a leaking mitral valve. The device is called MitraClip, and it is placed in the heart in a less invasive manner that uses a catheter. We want to know how well this device works compared to standard mitral valve repair surgery, which is a more invasive procedure.

Compensation: No
Ages: 18-110
Non-Oncology
Duke University Hospital
Skin Cancer - Melanoma

We are doing this study to find out if an experimental study drug called RP1 is a safe and effective treatment for your cancer. We want to know how the drug works on its own and when it is combined with a cancer drug called nivolumab.

Compensation: Yes
Ages: 18-110
Oncology
Duke University Hospital

We are doing this study to find out if a drug called rosuvastatin (an FDA-approved medication for lowering cholesterol) can help reduce symptoms and extend the life expectancy of people with liver cirrhosis. Although rosuvastatin is an approved and commonly prescribed drug, it is not approved for the treatment of cirrhosis.

Compensation: Yes
Ages: 18-75
Duke University Hospital
Kidneys, Bladder and Urinary System

We are doing this study to find out if a medical technology called the Revi System active therapy (system is being implanted and activated) is better than non-active Revi system therapy (system is being implanted but not activated) for the treatment of urinary urge incontinence (UUI).

Compensation: Yes
Ages: 18-110
Non-Oncology
Other
Eyes and Vision

We are doing this study to find out is an experimental drug called RGX-314 can help improve or preserve vision. We will compare how this drug works to Eylea®, which is an approved therapy for age-related macular degeneration.

Compensation: Yes
Ages: 50-89
Non-Oncology
Duke University Hospital