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432 clinical trials found.
Head and Neck Cancer

We are doing this study to learn more about the olfactory receptor expression (which give us our sense of smell) and neurogenesis (creation of cells) in human olfactory tissue.

Compensation: No
Oncology
Breast Cancer

We are doing this study to improve how cancer patients and their providers communicate with each other. We want to know how personal biases can affect how cancer care is explained and managed. We think being able to identify bias if any exists can improve care and patients' psychological well-being.

Compensation: Yes
Ages: 21-110
Oncology
Duke University Hospital, Duke Raleigh Hospital, Other
Infectious Diseases

We are doing this study to learn more about how genetics influence vulnerability and resistance to different types of infections.

Compensation: No
Ages: 18-110
Non-Oncology
Duke University Hospital
Brain, Spinal Cord and Nerves

We are doing this study to compare activity in the brains of female adults who have chronic pain and/or use opioids to the brain activity of healthy female adults who are pain-free. We hope this study can help us develop new and targeted treatments for adults with chronic pain and alternatives to opioid therapy.

Compensation: Yes
Ages: 18-65
Non-Oncology
Duke University Hospital
Research for Children and Teenagers

We are doing this study to find out what pain management options work best for most children who have surgery to remove their tonsils (tonsillectomy). We will compare the outcomes of using fentanyl (a short-acting opioid) versus using methadone (a long-acting opioid) to control pain during and after surgery. Both drugs are commonly used for this purpose, but we don't have enough data to know which is the best option to reduce pain.

Compensation: Yes
Ages: 3-17
Non-Oncology
Duke University Hospital, Duke Regional Hospital
Breast Cancer

We are doing this study to find out what strategy after surgery has the best outcomes for patients with triple-negative breast cancer who have a complete response to chemotherapy before their surgeries. We want to compare 27 weeks of treatment with pembrolizumab after surgery to 27 weeks of monitoring without drug treatment and find out if there is a difference in terms of risk of having the cancer come back.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital, Duke Raleigh Hospital
Thoracic Cancer

We are doing this study to find out if an experimental drug called ORIC-114 (the study drug) is a safe and effective option for possible treatment in patients with advanced solid tumors harboring an EGFR or HER2 alteration.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Mental Health, Behavior, and Substance Abuse

We are doing this study to improve treatment options for people with opioid use disorder. We want to know if a certain brain signal can better predict how someone will respond to buprenorphine (Suboxone®), and we also want to find out if a non-invasive treatment called repetitive Transcranial Magnetic Stimulation (rTMS) can help people quit opioids more easily than just taking buprenorphine alone. rTMS involves placing a coil against the scalp, and delivers magnetic pulses that stimulate a specific part of the brain. For this study, we will focus on the part of the brain involved with self-control. This procedure is FDA-approved for depression and is commonly used in other addiction treatments (smoking cessation).

Compensation: Yes
Ages: 18-110
Non-Oncology
Duke University Hospital, Other