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The study starts with a screening period that lasts about 4 weeks and includes 1 or 2 visits. Treatment can last up to about 2 years with up to 43 visits. After treatment ends, follow-up continues for about 1 year with up to 6 visits. The study medicine is given through an IV every 3 weeks, and each visit lasts about 60 minutes. In Part 1 of the study, researchers test the medicine BMS 986525 by itself or with another medicine called nivolumab to find a safe dose. In Part 2, the chosen dose or doses are tested in larger groups. If more than one dose is available, a computer may randomly choose which dose a person receives.

We are doing this study to find out if patients with SAA who have not received previous treatment for this diagnosis can be treated safely and effectively with transplant as their first therapy.

We created this healthy volunteer registry for people who would like to participate in brain imaging research studies. These studies use structural and functional MRI data to study areas of the brain associated with movement, memory, attention, and perception.

We are doing this study to better understand women's preferences for and concerns about hormone replacement. We want to learn from women who have had their fallopian tubes and ovaries removed due to BRCA1 and BRCA2 mutations.

We are doing this study to try and find a way to detect breast cancer earlier or before it recurs.

This study has three parts: 1. Getting Ready (Screening) - Takes up to 28 days - You'll get blood tests, a tissue sample, a TB test, and health checkups like scans and heart tests. 2. Treatment (Study Dosing) - People are grouped by race - You'll be randomly picked to get either regular chemo or chemo plus a study medicine (tocilizumab) - Medicine is given every 4 weeks - You'll keep doing health checkups and answer questions. 3. After Treatment (Follow-up) - Happens within 30 days after your last dose - More health checkups and questions to see how you're doing.

This study has three parts: 1. Screening Period (about 10 days): You will go to the clinic for tests like a brain scan (MRI), blood tests, heart check (EKG), and physical and brain exams. 2. Study Dosing Period: You will get a medicine called BRiTE through a small tube in your vein using a portable pump. It will run for 4 days. Then, you will not get any medicine for 24 days. This is called one cycle. You will go through 3 cycles like this. 3. Follow-Up Period: Doctors will keep checking on you with exams, blood tests, heart checks, and brain scans. You will visit the clinic every 8 weeks to make sure everything is going well.