Clinical Trials Directory

444 clinical trials found.
Heart and Circulation

We are doing this study to compare treatment options for mitral valve regurgitation.

Compensation: No
Ages: 60-110
Non-Oncology
Duke University Hospital
Primary Brain and Spinal Cord Tumors

We are doing this study to find out if an investigational drug called CA-4948 is a safe and effective option for people with PCNSL. We want to know how well it works when it is combined with a drug called ibrutinib, which is commonly used to treat PCNSL.

Compensation: Yes
Ages: 18-110
Oncology
Duke University Hospital
Hematologic Malignancies and Cellular Therapy

We are doing this study to find out if an experimental drug called CT01681 (the study drug) is a safe and effective option for people who get CAR T-cell therapy as a treatment for diffuse large B cell lymphoma (DLBCL). We want to know if the study drug has the potential to lower or prevent certain side effects of CAR T-cell therapy. The possible side effects of CAR T-cell therapy that the study drug is being developed to protect against are called cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome. This study is enrolling people who will receive an available form of CAR T-cell therapy called YESCARTA.

Compensation: No
Oncology
Primary Brain and Spinal Cord Tumors

We are doing this study to see if an experimental combination of drugs (D2C7-IT and 2141-V11) is a safe treatment for brain tumors.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Breast Cancer

We are doing this study to learn more about the use of the da Vinci Single-Port Surgical System in nipple-sparing mastectomy (NSM) procedures. We want to find out if the outcomes of NSM using this robotic-assisted technology are better than the current standard of open surgery.

Compensation: Yes
Ages: 21-110
Oncology
Duke University Hospital
Gastrointestinal Cancer

We are doing this study to collect information about how well dabrafenib plus trametinib works in patients who have unresectable (cannot be removed by surgery) or metastatic BRAF V600E mutation positive solid tumors.

Compensation: No
Oncology
Skin Cancer - Melanoma

We are doing this study to find out if the combination of the drugs Dapansutrile and Pembrolizumab is a safe and effective treatment for people with melanoma that does not improve after PD-1 therapy.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Biobank / Biospecimen Collections

We are doing this study to collect and store information and samples that will be used for future research studies about transplants.

Compensation: No
Ages: 0-100
Non-Oncology
Duke University Hospital