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484 clinical trials found.
Brain and Spine Metastasis

We are doing this study to collect blood and cerebrospinal fluid samples from patients who have breast cancer that has spread to the brain and/or spinal cord. We hope that by analyzing these samples, we can find out how effective different cancer medications are at treating metastases to the leptomeninges (tissue that surrounds the brain and spinal cord). We also want to do genetic testing on these samples to look for cancer mutations that can give us clues about how people might respond to different therapies or which therapies are most likely to be helpful.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Hematologic Malignancies and Cellular Therapy

We are doing this study to find out if an experimental technology is a safe and effective way to administer treatment for relapsed and/or refractory multiple myeloma (RRMM). We want to know if giving the drug isatuximab as an injection under the skin works as well as giving this same drug as an intravenous (IV) infusion. The drug combination of isatuximab, carfilzomib, and dexamethasone is approved for the treatment of RRMM, but the current standard of care is to give isatuximab through an IV.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Eyes and Vision

If you join this study, you will go to the study clinic at least ten times over about twenty seven months. Most visits will last two days, but some visits may take three days if needed. You will be placed by chance into one of two groups. One group will receive the study medicine, and the other group will receive a sham injection, which looks like a real injection but has no medicine.

Compensation: Yes
Ages: 8-110
Non-Oncology
Duke University Hospital
Lungs and Breathing

We will collect health information from medical records and biologic samples at standard of care visits related to your lung transplant. Samples collected may include blood, tissue, and fluids.

Compensation: No
Ages: 18-110
Non-Oncology
Duke University Hospital
Gastrointestinal Cancer

We are doing this study to find out if an experimental drug called LY3962673 (the study drug) is a safe and effective option for cancer that has a KRAS G12D mutation. We are also trying to find the best dose level to use.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Skin, Hair and Nails

We are doing this study to find out if an experimental drug called upadacitinib (the study drug) is a safe and effective option for people with moderate to severe hidradenitis suppurativa (HS) who did not get adequate relief from standard treatment.

Compensation: Yes
Ages: 12-110
Non-Oncology
Duke University Hospital
Heart and Circulation

We are doing this study to learn more about the sounds coming from a Doppler device when testing arteries. The recording will be used to train a computer program to compare the sounds from healthy arteries to non-healthy arteries.

Compensation: No
Non-Oncology
Research for Healthy Adults

We are doing this study to understand how environmental exposures may be involved in lung function. We want to find out how immune cells in the lungs are affected by irritants that are present in the environment.

Compensation: Yes
Ages: 18-55
Non-Oncology
Duke University Hospital, Other