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431 clinical trials found.
Hematologic Malignancies and Cellular Therapy

We are doing this study to find out if 2 different experimental drug combinations can improve outcomes for people who are newly diagnosed with AML. We want to compare the outcomes from the standard treatment (cytarabine + daunorubicin) to the following experimental regimens:

  • Venetoclax + cytarabine + daunorubicin
  • Venetoclax + azacitidine

Compensation: No
Ages: 18-59
Oncology
Duke University Hospital
Hematologic Malignancies and Cellular Therapy

We are doing this study to compare different experimental drug regimens to the usual treatment (cytarabine and daunorubicin) for acute myeloid leukemia (AML). We want to find out which options have the best outcomes. The different drug combinations we will be testing against the usual treatment are:

  • daunorubicin and cytarabine liposome
  • cytarabine and daunorubicin with venetoclax
  • azacitidine and venetoclax
  • daunorubicin and cytarabine liposome with venetoclax

Compensation: No
Ages: 18-59
Oncology
Duke University Hospital
Hematologic Malignancies and Cellular Therapy

We are doing this study to see if blood and bone marrow samples can be tested in a timely manner that allows for the detection of certain markers that could guide cancer treatment.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Research for Healthy Adults

We are doing this study to find out if an investigational vaccine (HydroVax-005 CHIKV - the study vaccine) is a safe and effective option to protect against chikungunya virus. Chikungunya virus is spread by mosquitos that are most common in Africa, Asia, and India. Infection with the virus can cause serious disease in older adults, children, and people with weaker immune systems.

Compensation: Yes
Ages: 18-49
Non-Oncology
Other
Research for Healthy Adults

We are doing this study to test an experimental simulation of "extravehicular activities" (EVAs), which are more commonly known as spacewalks. We want to know if this simulation will provide good training for astronauts who will have to perform EVAs during their space missions.

Compensation: Yes
Ages: 18-50
Non-Oncology
Duke University Hospital
COVID-19

We are doing this study to learn more about changes in nasal tissue in people that have COVID-19. Many COVID-19 patients have reported a change in sense of smell and we would like to find out why that is.

Compensation: No
Non-Oncology
Research for Children and Teenagers

We are using you or your child's medical information in this study to better understand the diagnosis, treatment, and complications of Spina Bifida.

Compensation: No
Ages: 0-110
Non-Oncology
Remote/online, Duke University Hospital
Brain, Spinal Cord and Nerves

We created the Registry for Brain Health to help you improve your brain health and get involved in research studies. The number of people in North Carolina affected by memory disorders, such as Alzheimer's disease and other forms of dementia, is going up. To change that, we must work together, stay informed, and get involved. We are enrolling both people who have memory problems and people who are healthy and do not have memory problems.

Compensation: No
Ages: 18-110
Non-Oncology
Other