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We are doing this study to find out how an experimental drug called sotorasib works in your body and against your cancer. We will compare how this drug works alone and in combination with several different drugs.

We are doing this study to compare how safe and effective different drug combinations are for treating metastatic cancer.

We are doing this study to find out if it is necessary to treat people with antibiotics after nasal surgery. We want to know if antibiotics are helpful or not during the healing process after surgery.

If you choose to join this study, you will:

• Have tumor tissue from a biopsy sent to a lab for genetic testing
• Get an assignment to a study if your tumor tissue has a genetic change that is targeted by one or more of the drugs being tested in this study

We are doing this study to find out if an experimental drug called APL-5125 (the study drug) is a safe and effective for people with select types of gastrointestinal cancer. We are also trying to find the best dose of APL-5125 to use.

We are doing this study to see if people have the L1 gene called apolipoprotein (APOL1) and to learn how this may affect them.

We are doing this study to learn more about the safety and effectiveness of the Medtronic Intrepid Transcatheter Mitral Valve Replacement System.   

We are doing this study to see if the study drugs, domvanalimab and zimberelimab, are safe and effective for treating advanced or metastatic gastroesophageal adenocarcinoma.