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438 clinical trials found.
Research for Healthy Adults

If you agree to be in the study, you will have 1 study visit that will last about 4 hours. The visit will include asking questions about your medical history, vital signs, pulmonary function tests (PFTs) and an MRI (magnetic resonance image) of the chest with inhaled Xenon gas. Someone from the study team will contact you about 24 hours after your study visit.

Compensation: Yes
Ages: 18-110
Non-Oncology
Duke University Hospital
Immunology and Rheumatology

We are doing this study to find out if an experimental drug called dazodalibep (the study drug) can improve symptoms for people who have Sjogren's Syndrome.

Compensation: Yes
Ages: 18-110
Non-Oncology
Duke University Hospital
Breast Cancer

We are doing this study to analyze biomarker responses to different drug regimens used for people who have HER2- and HER2+ breast cancer. We hope what we learn from the study can help us develop better treatments and figure out which treatment option(s) will be best for breast cancer patients.

Compensation: No
Ages: 18-90
Oncology
Duke University Hospital, Duke Raleigh Hospital
Phase I

We are doing this study to find the most effective, safe dose of an experimental drug called IAM1363 (the study drug) for people who have advanced cancers harboring HER2 alterations.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Hematologic Malignancies and Cellular Therapy

We are doing this study to find the most effective, safe dose of an experimental drug called iberdomide (the study drug). We want to know how well this study drug works in people with multiple myeloma when compared with a drug called lenalidomide after an autologous stem cell transplant.

Compensation: No
Oncology
Lungs and Breathing

This study is a biorepository (storehouse) where samples and data from critically ill patients with COVID-19 are stored. The reason for this study is to develop a collection of samples and data that can be shared with other doctors and researchers to help them answer important questions about the virus and possibly help develop treatments and tests for the future. Este estudio es un registro central para guardar información y muestras de pacientes críticamente enfermos en una Unidad de Cuidados Intensivos (ICU) que tienen COVID-19 El objetivo de este estudio es crear una colección de información y muestras que pueda ser compartida con otros médicos y otros investigadores para ayudar a responder preguntas importantes sobre el virus, y posiblemente desarrollar tratamientos y pruebas de detección en el futuro.

Compensation: No
Ages: 18-110
Non-Oncology
Duke University Hospital
Skin Cancer - Melanoma

We are doing this study to find out if an experimental drug called IDE196 (the study drug) in combination with crizotinib is a safe and effective treatment for uveal melanoma (melanoma in the eye) that has spread to another part of the body.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital, Duke Raleigh Hospital
Brain and Spine Metastasis

We are doing this study to find out if an experimental drug called IDE196 (the study drug) is a safe and effective treatment for uveal melanoma (melanoma in the eye) that has spread to another part of the body or other types of cancer with a tumor mutation in genes called GNAQ, GNA11, or PRKC.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital