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440 clinical trials found.
Phase I

We are doing this study to find the most effective, safe dose of an experimental drug called IAM1363 (the study drug) for people who have advanced cancers harboring HER2 alterations.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Hematologic Malignancies and Cellular Therapy

We are doing this study to find the most effective, safe dose of an experimental drug called iberdomide (the study drug). We want to know how well this study drug works in people with multiple myeloma when compared with a drug called lenalidomide after an autologous stem cell transplant.

Compensation: No
Oncology
Lungs and Breathing

We are doing this study to compare the outcomes and results of two newer asthma relief therapies (called MART and PARTICS). We want to know if either option seems to be more effective for most people with moderate-to-severe asthma.

Compensation: Yes
Ages: 18-75
Non-Oncology
Remote/online
Lungs and Breathing

This study is a biorepository (storehouse) where samples and data from critically ill patients with COVID-19 are stored. The reason for this study is to develop a collection of samples and data that can be shared with other doctors and researchers to help them answer important questions about the virus and possibly help develop treatments and tests for the future. Este estudio es un registro central para guardar información y muestras de pacientes críticamente enfermos en una Unidad de Cuidados Intensivos (ICU) que tienen COVID-19 El objetivo de este estudio es crear una colección de información y muestras que pueda ser compartida con otros médicos y otros investigadores para ayudar a responder preguntas importantes sobre el virus, y posiblemente desarrollar tratamientos y pruebas de detección en el futuro.

Compensation: No
Ages: 18-110
Non-Oncology
Duke University Hospital
Brain and Spine Metastasis

We are doing this study to find out if an experimental drug called IDE196 (the study drug) is a safe and effective treatment for uveal melanoma (melanoma in the eye) that has spread to another part of the body or other types of cancer with a tumor mutation in genes called GNAQ, GNA11, or PRKC.

Compensation: No
Ages: 18-110
Oncology
Duke University Hospital
Eyes and Vision

We are doing this study to learn more about how different factors affect people with two types of dry eye conditions: Sjögren's dry eye (SjD) and non-Sjögren's dry eye. Specifically, we want to know how neurotrophic keratitis (a condition where the cornea loses sensation) versus the severity of tear film and eye surface issues impact the structure and function of the cornea (the clear front part of the eye). We also want to find out if having dry eyes leads to less feeling in the cornea, and if this reduced feeling is linked to eye pain or pain in other parts of the body.

Compensation: No
Ages: 18-110
Non-Oncology
Duke University Hospital
Hematologic Malignancies and Cellular Therapy

We are doing this study to compare the outcomes of people who get their after-transplant care in the hospital versus in their home. This study is important to learn if getting after-transplant care in a patient's home can lead to better outcomes.

Compensation: Yes
Ages: 18-80
Oncology
Duke University Hospital, Other
Eyes and Vision

We are doing this study learn more about how we can identify potential biomarkers in your eyes that may let us predict and/or diagnose one or more illnesses or medical conditions. Although we will not be able to make these diagnoses now, one day in the future we may be able to use the information we have learned now to make these diagnoses in other people:

  • Alzheimer's disease
  • Mild cognitive impairment
  • Parkinson's disease
  • Frontotemporal dementia
  • Dementia of Lewy body
  • Multiple sclerosis
  • Traumatic Brain Injury
  • PTSD
  • ALS
  • Huntington's
  • Down syndrome

Compensation: No
Non-Oncology